Plays a central role in autophagy. Acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2. Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex forms. Involved in endocytosis. Protects against infection by a neurovirulent strain of Sindbis virus. May play a role in antiviral host defense.Beclin-1-C 35 kDa localized to mitochondria can promote apoptosis; it induces the mitochondrial translocation of BAX and the release of proapoptotic factors.

Beclin-1 (Coiled-coil myosin-like BCL2-interacting protein) (Protein GT197) [Cleaved into: Beclin-1-C 35 kDa; Beclin-1-C 37 kDa] BECN1 GT197

Human, Mouse, Rat

Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus

WB,IHC

WB 1:500-1:2000
IHC 1:50-1:500

60kD; 52kDa(Calculated).

BECN1 GT197

q14457

https://www.uniprot.org/uniprotkb/q14457

Rabbit

Polyclonal

Rabbit IgG

Phospho-Beclin 1 (Ser15) Antibody detects endogenous levels of Beclin 1 only when phosphorylated at Ser15.

Apoptosis #Autophagy #Cell division

PBS,pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol

Store at -20 °C. Stable for 12 months from date of receipt.