Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. The miRNA pathway on the other side is a mean to specifically regulate the expression of target genes.

Endoribonuclease Dicer (EC 3.1.26.3) (Helicase with RNase motif) (Helicase MOI) DICER1 DICER HERNA KIAA0928

Human, Mouse, Rat

Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus

WB,IHC

WB 1:500-1:2000
IHC 1:50-1:500

219kD; 219kDa(Calculated).

DICER1 DICER HERNA KIAA0928

q9upy3

https://www.uniprot.org/uniprotkb/q9upy3

Rabbit

Polyclonal

Rabbit IgG

Dicer Antibody detects endogenous levels of total Dicer.

PBS,pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol

Store at -20 °C. Stable for 12 months from date of receipt.