Catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. May have an important role in producing the neuromodulator gamma-hydroxybutyrate (GHB). Has broad substrate specificity. Has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). Can reduce 1,2-naphthoquinone and 9,10-phenanthrenequinone (in vitro). Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen.

Aflatoxin B1 aldehyde reductase member 2 (EC 1.1.1.n11) (AFB1 aldehyde reductase 1) (AFB1-AR 1) (Aldoketoreductase 7) (Succinic semialdehyde reductase) (SSA reductase) AKR7A2 AFAR AFAR1 AKR7

Human, Mouse

WB,IHC,ELISA

WB 1:1000-1:5000
IHC 1:20-1:200
ELISA 1:5000-1:20000

39.589 kDa ;

AKR7A2 AFAR AFAR1 AKR7

o43488

https://www.uniprot.org/uniprotkb/o43488

Recombinant Human Aflatoxin B1 aldehyde reductase member 2 protein (100-359AA)

Rabbit

Polyclonal

IgG

Neuroscience; Cancer; Metabolism; Signal transduction

>95%, Antigen Affinity Purified

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Store at -20°C. Do not aliquot the antibody