Transmembrane glycoprotein of the endoplasmic reticulum that functions as a transcription activator and initiates the unfolded protein response (UPR) during endoplasmic reticulum stress. Cleaved upon ER stress, the N-terminal processed cyclic AMP-dependent transcription factor ATF-6 alpha translocates to the nucleus where it activates transcription of genes involved in the UPR. Binds DNA on the 5\\'-CCAC[GA]-3\\'half of the ER stress response element (ERSE) (5\\'-CCAAT-N(9)-CCAC[GA]-3\\') and of ERSE II (5\\'-ATTGG-N-CCACG-3\\'). Binding to ERSE requires binding of NF-Y to ERSE. Could also be involved in activation of transcription by the serum response factor. May play a role in foveal development and cone function in the retina.

Cyclic AMP-dependent transcription factor ATF-6 alpha (cAMP-dependent transcription factor ATF-6 alpha) (Activating transcription factor 6 alpha) (ATF6-alpha) [Cleaved into: Processed cyclic AMP-dependent transcription factor ATF-6 alpha] ATF6

Human

IHC,IF,ICC,ELISA

IHC 1:100-1:500
IF 1:100-1:500
ICC 1:100-1:400
ELISA 1:5000-1:20000

74.585 kDa ;

ATF6

p18850

https://www.uniprot.org/uniprotkb/p18850

Recombinant Human Cyclic AMP-dependent transcription factor ATF-6 alpha protein (1-194AA)

Rabbit

Polyclonal

IgG

Signal Transduction

>95%, Antigen Affinity Purified

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Store at -20°C. Do not aliquot the antibody