Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5\\\\\\'-GTGACGT[AG][AG]-3\\\\\\'), a sequence present in many viral and cellular promoters. Activator of the NF-ELAM1/delta-A site of the E-selectin promoter. Has no intrinsic transcriptional activity, but activates transcription on formation of JUN or FOS heterodimers. Also can bind TRE promoter sequences when heterodimerized with members of the JUN family. Isoform 4/ATF-A0 acts as a dominant repressor of the E-selectin/NF-ELAM1/delta-A promoter. Isoform 5/ATF-4 acts as a negative regulator, inhibiting both ATF2 and ATF7 transcriptional activities. It may exert these effects by sequestrating in the cytoplasm the Thr-53 phosphorylating kinase, preventing activation.

Cyclic AMP-dependent transcription factor ATF-7 (cAMP-dependent transcription factor ATF-7) (Activating transcription factor 7) (Transcription factor ATF-A) ATF7 ATFA

Human

IHC,ELISA

IHC 1:20-1:200
ELISA 1:5000-1:20000

51.757 kDa ;

ATF7 ATFA

p17544

https://www.uniprot.org/uniprotkb/p17544

Recombinant Human Cyclic AMP-dependent transcription factor ATF-7 protein (1-117AA)

Rabbit

Polyclonal

IgG

Epigenetics and Nuclear Signaling

>95%, Antigen Affinity Purified

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Store at -20°C. Do not aliquot the antibody