Non-receptor tyrosine kinase involved in B-lymphocyte development, differentiation and signaling. B-cell receptor (BCR) signaling requires a tight regulation of several protein tyrosine kinases and phosphatases, and associated coreceptors. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. Signaling through BLK plays an important role in transmitting signals through surface immunoglobulins and supports the pro-B to pre-B transition, as well as the signaling for growth arrest and apoptosis downstream of B-cell receptor. Specifically binds and phosphorylates CD79A at \\\\\\'Tyr-188\\\\\\'and \\\\\\'Tyr-199\\\\\\', as well as CD79B at \\\\\\'Tyr-196\\\\\\' and \\\\\\'Tyr-207\\\\\\'. Phosphorylates also the immunoglobulin G receptors FCGR2A, FCGR2B and FCGR2C. With FYN and LYN, plays an essential role in pre-B-cell receptor (pre-BCR)-mediated NF-kappa-B activation. Contributes also to BTK activation by indirectly stimulating BTK intramolecular autophosphorylation. In pancreatic islets, acts as a modulator of beta-cells function through the up-regulation of PDX1 and NKX6-1 and consequent stimulation of insulin secretion in response to glucose.

Tyrosine-protein kinase Blk (EC 2.7.10.2) (B lymphocyte kinase) (p55-Blk) BLK

Human

IHC,ELISA

IHC 1:20-1:200
ELISA 1:5000-1:20000

57.706 kDa ;

BLK

p51451

https://www.uniprot.org/uniprotkb/p51451

Recombinant Human Tyrosine-protein kinase Blk protein (1-280AA)

Rabbit

Polyclonal

IgG

Transmembrane

Cell biology

>95%, Antigen Affinity Purified

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Store at -20°C. Do not aliquot the antibody