Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Functions as a ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity.

Probable E3 ubiquitin-protein ligase DTX2 (EC 2.3.2.27) (Protein deltex-2) (Deltex2) (hDTX2) (RING finger protein 58) (RING-type E3 ubiquitin transferase DTX2) DTX2 KIAA1528 RNF58

Human

WB,IHC,ELISA

WB 1:1000-1:5000
IHC 1:20-1:200
ELISA 1:5000-1:20000

67.246 kDa ;

DTX2 KIAA1528 RNF58

q86uw9

https://www.uniprot.org/uniprotkb/q86uw9

Recombinant Human Probable E3 ubiquitin-protein ligase DTX2 protein (1-280AA)

Rabbit

Polyclonal

IgG

Stem cells

>95%, Antigen Affinity Purified

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Store at -20°C. Do not aliquot the antibody