Serine/threonine-protein kinase involved in transcription regulation and TNF-mediated cellular apoptosis. Plays a role as a corepressor for homeodomain transcription factors. Phosphorylates DAXX and MYB. Phosphorylates DAXX in response to stress, and mediates its translocation from the nucleus to the cytoplasm. Inactivates MYB transcription factor activity by phosphorylation. Prevents MAP3K5-JNK activation in the absence of TNF. TNF triggers its translocation to the cytoplasm in response to stress stimuli, thus activating nuclear MAP3K5-JNK by derepression and promoting apoptosis. May be involved in anti-oxidative stress responses. Involved in the regulation of eye size, lens formation and retinal lamination during late embryogenesis. Promotes angiogenesis and to be involved in erythroid differentiation. May be involved in malignant squamous cell tumor formation.

Homeodomain-interacting protein kinase 1 (EC 2.7.11.1) (Nuclear body-associated kinase 2) HIPK1 KIAA0630 MYAK NBAK2

Human

IHC,IF,ICC,ELISA

IHC 1:200-1:500
IF 1:50-1:200
ICC 1:100-1:400
ELISA 1:5000-1:20000

130.843 kDa ;

HIPK1 KIAA0630 MYAK NBAK2

q86z02

https://www.uniprot.org/uniprotkb/q86z02

Recombinant Human Homeodomain-interacting protein kinase 1 protein (1007-1151AA)

Rabbit

Polyclonal

IgG

Epigenetics and Nuclear Signaling; Signal transduction

>95%, Protein G purified

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Store at -20°C. Do not aliquot the antibody