G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal embryonic development of the adrenal gland and for normal hormonal responses to stress. Plays a role in the response to anxiogenic stimuli.

Corticotropin-releasing factor receptor 1 (CRF-R-1) (CRF-R1) (CRFR-1) (Corticotropin-releasing hormone receptor 1) (CRH-R-1) (CRH-R1) CRHR1 CRFR CRFR1 CRHR

Human

IHC,IF,ICC,ELISA

IHC 1:500-1:1000
IF 1:50-1:200
ICC 1:100-1:400
ELISA 1:5000-1:20000

50.719 kDa ;

CRHR1 CRFR CRFR1 CRHR

p34998

https://www.uniprot.org/uniprotkb/p34998

Recombinant Human Corticotropin-releasing factor receptor 1 protein (24-121AA)

Rabbit

Polyclonal

IgG

Transmembrane

Neuroscience; Cancer; Metabolism; Signal transduction

>95%, Protein G purified

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Store at -20°C. Do not aliquot the antibody