Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre-mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for estrogen receptor ESR1 and androgen receptor AR. Increases ESR1 AF-1 domain-mediated transactivation and ESR1 AF-1 and AF-2 domains transcriptional synergistic activity. Synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and involved in skeletal muscle differentiation. Transcriptional coactivator for p53/TP53 and involved in p53/TP53 transcriptional response to DNA damage and p53/TP53-dependent apoptosis. Transcriptional coactivator for RUNX2 and involved in regulation of osteoblast differentiation. Acts as transcriptional repressor in a promoter-specicic manner; the function probbaly involves association with histone deacetylases, such as HDAC1. As component of a large PER complex is involved in the inhibition of 3\\\\\\' transcriptional termination of circadian target genes such as PER1 and NR1D1 and the control of the circadian rhythms.

Probable ATP-dependent RNA helicase DDX5 (EC 3.6.4.13) (DEAD box protein 5) (RNA helicase p68) DDX5 G17P1 HELR HLR1

Human

WB,IHC,ELISA

WB 1:500-1:2000
IHC 1:20-1:200
ELISA 1:5000-1:20000

69.148 kDa ;

DDX5 G17P1 HELR HLR1

p17844

https://www.uniprot.org/uniprotkb/p17844

Recombinant Human Probable ATP-dependent RNA helicase DDX5 protein (1-290AA)

Rabbit

Polyclonal

IgG

Epigenetics and Nuclear Signaling

>95%, Antigen Affinity Purified

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Store at -20°C. Do not aliquot the antibody