Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates \\\\\\'Lys-9\\\\\\' and \\\\\\'Lys-27\\\\\\' of histone H3, leading to transcriptional repression of the affected target gene. Also recognizes \\\\\\'Lys-26\\\\\\' trimethylated histone H1 with the effect of inhibiting PRC2 complex methyltransferase activity on nucleosomal histone H3 \\\\\\'Lys-27\\\\\\', whereas H3 \\\\\\'Lys-27\\\\\\' recognition has the opposite effect, enabling the propagation of this repressive mark. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A.

Polycomb protein EED (hEED) (Embryonic ectoderm development protein) (WD protein associating with integrin cytoplasmic tails 1) (WAIT-1) EED

Human

WB,IHC,ELISA

WB 1:500-1:2000
IHC 1:20-1:200
ELISA 1:5000-1:20000

50.198 kDa ;

EED

o75530

https://www.uniprot.org/uniprotkb/o75530

Recombinant Human Polycomb protein EED protein (1-300AA)

Rabbit

Polyclonal

IgG

Nucleus localization

Epigenetics and Nuclear Signaling

>95%, Antigen Affinity Purified

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Store at -20°C. Do not aliquot the antibody