Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (eIF-2-alpha/EIF2S1) on \\'Ser-52\\' during the unfolded protein response (UPR) and in response to low amino acid availability. Converts phosphorylated eIF-2-alpha/EIF2S1 either in a global protein synthesis inhibitor, leading to a reduced overall utilization of amino acids, or to a translation initiation activator of specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1). Involved in control of mitochondrial morphology and function.

Eukaryotic translation initiation factor 2-alpha kinase 3 (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase) (HsPEK) EIF2AK3 PEK PERK

Human

IHC,IF,ICC,ELISA

IHC 1:200-1:500
IF 1:50-1:200
ICC 1:100-1:400
ELISA 1:5000-1:20000

125.216 kDa ;

EIF2AK3 PEK PERK

q9nzj5

https://www.uniprot.org/uniprotkb/q9nzj5

Recombinant Human Eukaryotic translation initiation factor 2-alpha kinase 3 protein (115-330AA)

Rabbit

Polyclonal

IgG

Transmembrane

Epigenetics and Nuclear Signaling; Metabolism

>95%, Protein G purified

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Store at -20°C. Do not aliquot the antibody