Functions as guanine nucleotide exchange factor that activates RAC1. May have relatively low activity. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. Plays a role in TNFSF11-mediated osteoclast differentiation, especially in podosome rearrangement and reorganization of the actin cytoskeleton. Regulates the activation of ITGB3, integrin signaling and cell adhesion (By similarity).

FERM, ARHGEF and pleckstrin domain-containing protein 2 (FERM domain-including RhoGEF) (FIR) (FERM, RhoGEF and pleckstrin domain-containing protein 2) (Pleckstrin homology domain-containing family C member 3) (PH domain-containing family C member 3) FARP2 KIAA0793 PLEKHC3

Human

IHC,IF,ICC,ELISA

IHC 1:20-1:200
IF 1:50-1:200
ICC 1:100-1:400
ELISA 1:5000-1:20000

119.888 kDa ;

FARP2 KIAA0793 PLEKHC3

o94887

https://www.uniprot.org/uniprotkb/o94887

Recombinant Human FERM, ARHGEF and pleckstrin domain-containing protein 2 protein (261-550AA)

Rabbit

Polyclonal

IgG

Neuroscience; Signal transduction

>95%, Protein G purified

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Store at -20°C. Do not aliquot the antibody