Transcription factor involved in the regulation of the insulin signaling pathway. Binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. Down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. Also involved in negative regulation of the cell cycle. Involved in increased proteasome activity in embryonic stem cells (ESCs) by activating expression of PSMD11 in ESCs, leading to enhanced assembly of the 26S proteasome, followed by higher proteasome activity.

Forkhead box protein O4 (Fork head domain transcription factor AFX1) FOXO4 AFX AFX1 MLLT7

Human

IHC,IF,ICC,ELISA

IHC 1:20-1:200
IF 1:50-1:200
ICC 1:100-1:400
ELISA 1:5000-1:20000

53.684 kDa ;

FOXO4 AFX AFX1 MLLT7

p98177

https://www.uniprot.org/uniprotkb/p98177

Peptide sequence from Human Forkhead box protein O4 protein (45-63AA)

Rabbit

Polyclonal

IgG

Epigenetics and Nuclear Signaling; Cancer; Cardiovascular; Cell biology; Metabolism

>95%, Antigen Affinity Purified

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Store at -20°C. Do not aliquot the antibody