Essential for cardiac morphogenesis, particularly for the formation of the right ventricle and of the aortic arch arteries. Required for vascular development and regulation of angiogenesis, possibly through a VEGF signaling pathway. Plays also an important role in limb development, particularly in the establishment of anterior-posterior polarization, acting as an upstream regulator of sonic hedgehog (SHH) induction in the limb bud. Is involved in the development of branchial arches, which give rise to unique structures in the head and neck. Binds DNA on E-box consensus sequence 5\\\\\\'-CANNTG-3\\\\\\' (By similarity).

Heart- and neural crest derivatives-expressed protein 2 (Class A basic helix-loop-helix protein 26) (bHLHa26) (Deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2) (dHAND) HAND2 BHLHA26 DHAND

Human

IHC,ELISA

IHC 1:20-1:200
ELISA 1:5000-1:20000

23.666 kDa ;

HAND2 BHLHA26 DHAND

p61296

https://www.uniprot.org/uniprotkb/p61296

Recombinant Human Heart- and neural crest derivatives-expressed protein 2 protein (1-217AA)

Rabbit

Polyclonal

IgG

Nucleus localization

Epigenetics and Nuclear Signaling; Neuroscience; Cardiovascular

>95%, Antigen Affinity Purified

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Store at -20°C. Do not aliquot the antibody