Acts as a transcriptional regulator that recognizes and binds to the sequence 5\\\\\\'-[GA]TTA[CT]GTAA[CT]-3\\\\\\', a sequence present in many cellular and viral promoters. Represses transcription from promoters with activating transcription factor (ATF) sites. Represses promoter activity in osteoblasts (By similarity). Represses transcriptional activity of PER1 (By similarity). Represses transcriptional activity of PER2 via the B-site on the promoter (By similarity). Activates transcription from the interleukin-3 promoter in T-cells. Competes for the same consensus-binding site with PAR DNA-binding factors (DBP, HLF and TEF) (By similarity). Component of the circadian clock that acts as a negative regulator for the circadian expression of PER2 oscillation in the cell-autonomous core clock (By similarity). Protects pro-B cells from programmed cell death (By similarity).

Nuclear factor interleukin-3-regulated protein (E4 promoter-binding protein 4) (Interleukin-3 promoter transcriptional activator) (Interleukin-3-binding protein 1) (Transcriptional activator NF-IL3A) NFIL3 E4BP4 IL3BP1

Human

WB,IHC,ELISA

WB 1:1000-1:5000
IHC 1:20-1:200
ELISA 1:5000-1:20000

51.472 kDa ;

NFIL3 E4BP4 IL3BP1

q16649

https://www.uniprot.org/uniprotkb/q16649

Recombinant Human Nuclear factor interleukin-3-regulated protein (133-462AA)

Rabbit

Polyclonal

IgG

Nucleus localization

Epigenetics and Nuclear Signaling; Immunology

>95%, Antigen Affinity Purified

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Store at -20°C. Do not aliquot the antibody