Serine palmitoyltransferase (SPT). The heterodimer formed with SPTLC2 or SPTLC3 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. The SPTLC1-SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to use a broader range of acyl-CoAs, without apparent preference.

Serine palmitoyltransferase 1 (EC 2.3.1.50) (Long chain base biosynthesis protein 1) (LCB 1) (Serine-palmitoyl-CoA transferase 1) (SPT 1) (SPT1) SPTLC1 LCB1

Human

WB,IHC,ELISA

WB 1:500-1:2000
IHC 1:20-1:200
ELISA 1:5000-1:20000

52.744 kDa ;

SPTLC1 LCB1

o15269

https://www.uniprot.org/uniprotkb/o15269

Recombinant Human Serine palmitoyltransferase 1 protein (37-310AA)

Rabbit

Polyclonal

IgG

Transmembrane

Neuroscience; Cancer; Cardiovascular; Metabolism; Signal transduction

>95%, Antigen Affinity Purified

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Store at -20°C. Do not aliquot the antibody