Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity).

Calcium-responsive transactivator (SS18-like protein 1) (SYT homolog 1) SS18L1 CREST KIAA0693

Human, Mouse

WB,IHC,ELISA

WB 1:1000-1:5000
IHC 1:20-1:200
ELISA 1:5000-1:20000

42.990 kDa ;

SS18L1 CREST KIAA0693

o75177

https://www.uniprot.org/uniprotkb/o75177

Recombinant Human Calcium-responsive transactivator protein (47-396AA)

Rabbit

Polyclonal

IgG

Nucleus localization

Others

>95%, Protein G purified

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Store at -20°C. Do not aliquot the antibody