Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization (PubMed:26466680). Plays a role in cell protrusion formations; involved in cell polarity, lamellipodial assembly, membrane ruffling and macropinosome formations (PubMed:19846667, PubMed:26578515, PubMed:26466680). Involved as well in cell migration and invadopodia formation during wound healing (PubMed:19846667, PubMed:26578515, PubMed:26466680).

Capping protein, Arp2/3 and myosin-I linker protein 2 (Capping protein regulator and myosin 1 linker 2) (F-actin-uncapping protein RLTPR) (Leucine-rich repeat-containing protein 16C) (RGD, leucine-rich repeat, tropomodulin and proline-rich-containing protein) CARMIL2 LRRC16C RLTPR

Human

WB,IP,ELISA

WB 1:500-1:2000
IP 1:200-1:2000
ELISA 1:5000-1:20000

154.689 kDa ;

CARMIL2 LRRC16C RLTPR

q6f5e8

https://www.uniprot.org/uniprotkb/q6f5e8

Recombinant Human Capping protein, Arp2/3 and myosin-I linker protein 2 protein (1136-1290AA)

Rabbit

Polyclonal

IgG

Cell biology

>95%, Protein G purified

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Store at -20°C. Do not aliquot the antibody