Required for both basal and inducible autophagy. Determines the localization of the autophagy-specific PI3-kinase complex PI3KC3-C1 (PubMed:18843052, PubMed:19050071). Plays a role in autophagosome formation and MAP1LC3/LC3 conjugation to phosphatidylethanolamine (PubMed:19270696, PubMed:20713597). Promotes BECN1 translocation from the trans-Golgi network to autophagosomes (PubMed:20713597). Enhances PIK3C3 activity in a BECN1-dependent manner. Essential for the autophagy-dependent phosphorylation of BECN1 (PubMed:23878393). Stimulates the phosphorylation of BECN1, but suppresses the phosphorylation PIK3C3 by AMPK (PubMed:23878393). Binds to STX17-SNAP29 binary t-SNARE complex on autophagosomes and primes it for VAMP8 interaction to promote autophagosome-endolysosome fusion (PubMed:25686604). Modulates the hepatic lipid metabolism (By similarity).

Beclin 1-associated autophagy-related key regulator (Barkor) (Autophagy-related protein 14-like protein) (Atg14L) ATG14 ATG14L KIAA0831

Human, Mouse, Rat

WB,IHC,IF,ICC,ELISA

WB 1:200-1:5000
IHC 1:20-1:200
IF 1:50-1:200
ICC 1:100-1:400
ELISA 1:5000-1:20000

55.309 kDa ;

ATG14 ATG14L KIAA0831

q6zne5

https://www.uniprot.org/uniprotkb/q6zne5

Recombinant Human Beclin 1-associated autophagy-related key regulator protein (1-492AA)

Rabbit

Polyclonal

IgG

Signal transduction

>95%, Protein G purified

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Store at -20°C. Do not aliquot the antibody