Key negative regulator of Shh signaling, which promotes the processing of GLI3 into GLI3R during neural tube development. Recruited by TULP3 and the IFT-A complex to primary cilia and acts as a regulator of the PKA-dependent basal repression machinery in Shh signaling by increasing cAMP levels, leading to promote the PKA-dependent processing of GLI3 into GLI3R and repress the Shh signaling. In presence of SHH, it is removed from primary cilia and is internalized into recycling endosomes, preventing its activity and allowing activation of the Shh signaling. Its ligand is unknown (By similarity).

G-protein coupled receptor 161 (G-protein coupled receptor RE2) GPR161

Human

WB,IF,ICC,ELISA

WB 1:1000-1:5000
IF 1:50-1:200
ICC 1:100-1:400
ELISA 1:5000-1:20000

58.559 kDa ;

GPR161

q8n6u8

https://www.uniprot.org/uniprotkb/q8n6u8

Recombinant Human G-protein coupled receptor 161 protein (1-28AA)

Rabbit

Polyclonal

IgG

Transmembrane

Others

>95%, Protein G purified

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Store at -20°C. Do not aliquot the antibody