May indirectly participate in activation of the NF-kappa-B and MAPK pathways. Acts as a mediator of BMP4-mediated modulation of canonical Wnt signaling activity in neural stem cells. Required for DNA damage-induced ATM phosphorylation, p53 activation and cell cycle arrest. Involved in myelopoiesis. Transcription factor. Binds to the oxygen responsive element of COX4I2 and represses its transcription under hypoxia conditions (4% oxygen), as well as normoxia conditions (20% oxygen) (PubMed:23303788). May repress COX4I2 transactivation induced by CHCHD2 and RBPJ (PubMed:23303788).

CXXC-type zinc finger protein 5 (CF5) (Putative MAPK-activating protein PM08) (Putative NF-kappa-B-activating protein 102) (Retinoid-inducible nuclear factor) (RINF) CXXC5 HSPC195 TCCCIA00297

Human

IHC,ELISA

IHC 1:20-1:200
ELISA 1:5000-1:20000

32.977 kDa ;

CXXC5 HSPC195 TCCCIA00297

q7lfl8

https://www.uniprot.org/uniprotkb/q7lfl8

Recombinant Human CXXC-type zinc finger protein 5 protein (1-227AA)

Rabbit

Polyclonal

IgG

Epigenetics and Nuclear Signaling; Cancer; Cell biology; Signal transduction; Stem cells

>95%, Protein G purified

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Store at -20°C. Do not aliquot the antibody