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Note: Application as IHC, only suitable for histochemical staining or fluorescence staining of paraffin-embedded sections. Application as ICC/IF, suitable for histochemical or fluorescent staining of frozen sections, as well as chemical and fluorescent staining at the cellular level.
注意：抗体应用为IHC的，抗体只适合于石蜡切片的组化染色或者荧光染色。
抗体应用为IF/ICC的，抗体适合于冰冻切片的组化染色或者荧光染色，以及细胞水平的化学染色和荧光染色。
ABMART实验方案下载
Eukaryotic histones are basic and water soluble nuclear proteins that form hetero-octameric nucleosome particles by wrapping 146 base pairs of DNA sequentially in a left-handed super-helical turn to form chromosomal fiber. Two molecules of each of the four core histones (H2A, H2B, H3 and H4) form the octamer, which is comprised of two H2A-H2B dimers and two H3-H4 dimers, creating two nearly symmetrical halves by tertiary structure. More than 80% of nucleosomes contain the linker Histone H1, derived from an intronless gene, that interacts with linker DNA between nucleosomes and mediates compaction into higher order chromatin. Histones are subject to posttranslational modification by enzymes primarily on their N-terminal tails, but also in their globular domains. Such modifications include methylation, citrullination, acetylation, phosphorylation, sumoylation, ubiquitination and ADP-ribosylation.
Histone H2AX (H2a/x) (Histone H2A.X) H2ax H2a.x H2afx Hist5-2ax
Broad mammalian,Zebrafish,Drosophila,Xenopus,C. elegans
WB,IP
WB 1:100-1:1000IP 1-2 μg per 100-500 μg of total protein 1:ml of cell lysate
16 kDa
H2ax H2a.x H2afx Hist5-2ax
swissprot: p27661 mouse
Rabbit
Polyclonal
Rabbit IgG
Nucleus localization
DNA damage #DNA excision #Meiosis #Spermatogenesis
Most abundant in testis, thymus and spleen.
Immunogen affinity purified.
Liquid
1 mg/mL.
1*TBS (pH7.4), 1%BSA. Preservative: 0.05% Sodium Azide.
Store at +4℃ after thawing. For long-term storage, please store it at -20℃. Avoid repeated freeze / thaw cycles.
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订购专线：4006-123-828
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