IL-8, also known as neutrophil chemotactic factor, has two primary functions. It induces chemotaxis in target cells, primarily neutrophils but also other granulocytes, causing them to migrate toward the site of infection. IL-8 also stimulates phagocytosis once they have arrived. IL-8 is also known to be a potent promoter of angiogenesis. In target cells, IL-8 induces a series of physiological responses required for migration and phagocytosis, such as increases in intracellular Ca2+, exocytosis (e.g. histamine release), and the respiratory burst.IL-8 can be secreted by any cells with toll-like receptors that are involved in the innate immune response. Usually, it is the macrophages that see an antigen first, and thus are the first cells to release IL-8 to recruit other cells. Both monomer and homodimer forms of IL-8 have been reported to be potent inducers of the chemokine receptors CXCR1 and CXCR2. The homodimer is more potent, but methylation of Leu25 can block the activity of homodimers.

Interleukin-8 (IL-8) (C-X-C motif chemokine 8) (Chemokine (C-X-C motif) ligand 8) (Emoctakin) (Granulocyte chemotactic protein 1) (GCP-1) (Monocyte-derived neutrophil chemotactic factor) (MDNCF) (Monocyte-derived neutrophil-activating peptide) (MONAP) (Neutrophil-activating protein 1) (NAP-1) (Protein 3-10C) (T-cell chemotactic factor) [Cleaved into: MDNCF-a (GCP/IL-8 protein IV) (IL8/NAP1 form I); Interleukin-8 ((Ala-IL-8)77) (GCP/IL-8 protein II) (IL-8(1-77)) (IL8/NAP1 form II) (MDNCF-b); IL-8(5-77); IL-8(6-77) ((Ser-IL-8)72) (GCP/IL-8 protein I) (IL8/NAP1 form III) (Lymphocyte-derived neutrophil-activating factor) (LYNAP) (MDNCF-c) (Neutrophil-activating factor) (NAF); IL-8(7-77) (GCP/IL-8 protein V) (IL8/NAP1 form IV); IL-8(8-77) (GCP/IL-8 protein VI) (IL8/NAP1 form V); IL-8(9-77) (GCP/IL-8 protein III) (IL8/NAP1 form VI)] CXCL8 IL8

Human

WB,IHC,IF,ICC,FC

WB 1:2000
IHC 1:50-1:100
IF 1:100-1:400
ICC 1:500
FC 1:50-1:100

11 kDa

CXCL8 IL8

swissprot: p10145 human

https://www.uniprot.org/uniprotkb/p10145

Rabbit

Polyclonal

Rabbit IgG

Immunology->Innate Immunity->Cytokines->Interleukins;Cancer->Invasion/microenvironment->Apoptosis->Death receptors ligands->RIP;Cancer->Invasion/microenvironment->Apoptosis->Caspases;Cancer->Invasion/microenvironment->Apoptosis->Cytochrome C;Cancer->Invasion/microenvironment->Angiogenesis->Angiogenic growth factors;Cancer->Invasion/microenvironment->Angiogenesis->ECM enzymes->TIMPs;Cancer->Invasion/microenvironment->Angiogenesis->Angiogenic inhibitory factors;Cancer->Invasion/microenvironment->Hypoxia->Hypoxia-related proteins;Cancer->Tumor biomarkers->Tumor antigens;Cancer->Tumor biomarkers->Enzymes->Other

Mouse stomach tissue lysates, human tonsil tissue, human skeletal muscle tissue, AGS.

Protein affinity purified.

Liquid

1 mg/mL.

1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Store at +4℃ after thawing. For long-term storage, please store it at -20℃. Avoid repeated freeze / thaw cycles.