Note: Application as IHC, only suitable for histochemical staining or fluorescence staining of paraffin-embedded sections. Application as ICC/IF, suitable for histochemical or fluorescent staining of frozen sections, as well as chemical and fluorescent staining at the cellular level.
注意:抗体应用为IHC的,抗体只适合于石蜡切片的组化染色或者荧光染色。
抗体应用为IF/ICC的,抗体适合于冰冻切片的组化染色或者荧光染色,以及细胞水平的化学染色和荧光染色。
ABMART实验方案下载
Proteolipid protein 1 (PLP1) is a form of myelin proteolipid protein (PLP). Mutations in PLP1 are associated with Pelizaeus–Merzbacher disease. It is a 4 transmembrane domain protein which is proposed to bind other copies of itself on the extracellular side of the membrane. In a myelin sheath, as the layers of myelin wraps come together, PLP will bind itself and tightly hold the cellular membranes together.
This gene encodes a transmembrane proteolipid protein that is the predominant myelin protein present in the central nervous system (CNS). The encoded protein functions in myelination. This protein may play a role in the compaction, stabilization, and maintenance of myelin sheaths, as well as in oligodendrocyte development and axonal survival. Mutations associated with this gene cause X-linked Pelizaeus–Merzbacher disease and spastic paraplegia type 2. Two transcript variants encoding distinct isoforms have been identified for this gene.
In melanocytic cells PLP1 gene expression may be regulated by MITF.
Myelin proteolipid protein (PLP) (Lipophilin) PLP1 PLP
Human,Mouse,Rat
WB,IHC,IF,ICC
WB 1:5000IHC 1:2000IF 1:100-1:400ICC 1:50-1:100
Predicted Molecular Wt. 30 kDa
PLP1 PLP
swissprot: p60201 human;swissprot: p60202 mouse;swissprot: p60203 rat
Rabbit
Polyclonal
Rabbit IgG
Transmembrane
Neuroscience->Cell Adhesion Proteins->Membrane Proteins;Neuroscience->Cell Type Marker->Glia marker->Oligodendrocyte marker
HepG2 cell lysate, mouse cerebellum tissue lysate, mouse brain tissue lysate, rat brain tissue lysate, F9 cell, rat brain tissue, mouse brain tissue.
Peptide affinity purified.
Liquid
1 mg/mL.
1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Store at +4℃ after thawing. For long-term storage, please store it at -20℃. Avoid repeated freeze / thaw cycles.
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