13916964679
Note: Application as IHC, only suitable for histochemical staining or fluorescence staining of paraffin-embedded sections. Application as ICC/IF, suitable for histochemical or fluorescent staining of frozen sections, as well as chemical and fluorescent staining at the cellular level.
注意：抗体应用为IHC的，抗体只适合于石蜡切片的组化染色或者荧光染色。
抗体应用为IF/ICC的，抗体适合于冰冻切片的组化染色或者荧光染色，以及细胞水平的化学染色和荧光染色。
ABMART实验方案下载
Transient receptor potential cation channel, subfamily M, member 2, also known as TRPM2, is a protein that in humans is encoded by the TRPM2 gene. The TRPM2 gene is highly expressed in the brain and was implicated by both genetic linkage studies in families and then by case control or trio allelic association studies in the genetic aetiology of bipolar affective disorder (Manic Depression). The physiological role of TRPM2 is not well understood. It was shown to be involved in insulin secretion.[5][11] In the immune cells it mediates parts of the responses to TNF-alpha. A role has been suggested for TRPM2 in activation of NLRP3 inflammasome, the dysregulation of which is strongly associated with a number of auto inflammatory and metabolic diseases, such as gout, obesity and diabetes.[13] In the brain it is involved in the toxicity of amyloid beta, a protein associated with Alzheimer's disease.[14] In 2016, TRPM2 channel was strongly implicated in the detection of non-painful warm stimuli. Chun-Hsiang Tan and Peter McNaughton studied the responses of actual sensory neurons to thermal stimuli, then used an RNA-sequencing strategy to identify TRPM2 as genetically required for warmth detection in the non-noxious range of 33–38 °C.
Transient receptor potential cation channel subfamily M member 2 (Estrogen-responsive element-associated gene 1 protein) (Long transient receptor potential channel 2) (LTrpC-2) (LTrpC2) (Transient receptor potential channel 7) (TrpC7) (Transient receptor potential melastatin 2) TRPM2 EREG1 KNP3 LTRPC2 TRPC7
Human,Mouse,Rat
WB,FC
WB 1:500-1:1000FC 1:100-1:500
172 kDa
TRPM2 EREG1 KNP3 LTRPC2 TRPC7
swissprot: o94759 human;swissprot: q91yd4 mouse;swissprot: q5g856 rat
Rabbit
Polyclonal
Rabbit IgG
Transmembrane
Cell Biology->Other Antibodies->Oxidative Stress
THP-1 cell lysate, PC-3 cell lysate, rat cerebellum tissue, human bone tissue, mouse brain tissue, SH-SY5Y.
Peptide affinity purified.
Liquid
1 mg/mL.
1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Store at +4℃ after thawing. For long-term storage, please store it at -20℃. Avoid repeated freeze / thaw cycles.
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订购专线：4006-123-828
销售电话：13916964679（微信同号）
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程经理：手机18616261485（微信同号）
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徐经理：手机15618191473（微信同号）
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