Mitogen-activated protein kinase (MAPK) signaling pathways involve two closely related MAP kinases, known as extracellular-signal-related kinase 1 (ERK 1, p44) and 2 (ERK 2, p42). Growth factors, steroid hormones, G protein-coupled receptor ligands and neurotransmitters can initiate MAPK signaling pathways. Activation of ERK 1 and ERK 2 requires phosphorylation by upstream kinases such as MAP kinasekinase (MEK), MEK kinase and Raf-1. ERK 1 and ERK 2 phosphorylation can occur at specific tyrosine and threonine sites mapping within consensus motifs that include the threonine-glutamate-tyrosine motif. ERK activation leads to dimerization with other ERKs and subsequent localization to the nucleus. Active ERK dimers phosphorylate serine and threonine residues on nuclear proteins and influence a host of responses that include proliferation, differentiation, transcription regulation and development. The human ERK 1 gene maps to chromosome 16p11.2 and encodes a 379 amino acid protein that shares 83% sequence identity to ERK 2. The human ERK2 gene maps to chromosome 22q11.21 and encodes a 360-amino acid protein.

Mitogen-activated protein kinase 3 (MAP kinase 3) (MAPK 3) (EC 2.7.11.24) (ERT2) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase isoform p44) (p44-MAPK) (Microtubule-associated protein 2 kinase) (p44-ERK1) MAPK3 ERK1 PRKM3

Human,Mouse,Rat,Zebrafish

WB,IHC,IF,ICC,IP,FC

WB 1:5000-1:20000
IHC 1:20000
IF 1:200-1:500
ICC 1:2000
IP 1:50
FC 1:1000

42/44 kDa

MAPK3 ERK1 PRKM3

swissprot: p27361 human;swissprot: p28482 human;swissprot: p63085 mouse;swissprot: q63844 mouse;swissprot: p21708 rat;swissprot: p63086 rat

https://www.uniprot.org/uniprotkb/p27361

Rabbit

Monoclonal

Rabbit IgG

Neuroscience->Neurotransmission->Intracellular Signaling->Kinases;Neuroscience->Neurotransmission->Intracellular Signaling->Phosphatases;Neuroscience->Neurology process->Neurodegenerative disease->Alzheimer's disease->Tangles Tau;Cell Biology->Cell Cycle->Kinases/Phosphatases->Other;Cancer->Invasion/microenvironment->ECM->Cell adhesion->Other;Cancer->Invasion/microenvironment->Apoptosis->Other;Cancer->Invasion/microenvironment->Apoptosis->Death receptors ligands->IAPs;Cancer->Invasion/microenvironment->Apoptosis->Caspases;Cancer->Signal transduction->Protein phosphorylation->Serine/threonine kinases->AKT;Cancer->Cell Death->Apoptosis->Metabolism;Cancer->Cell Death->Apoptosis->Other;Cancer->Cell cycle->Kinases/phosphatases->Other

A431 cell lysate, MCF-7 cell lysate, SK-Br-3 cell lysate, Hela cell lysate, PC-12 cell lysate, hybrid fish (crucian-carp) brain tissue lysates, Hela, MCF-7, NIH/3T3, A549, SH-SY5Y.

Protein A affinity purified.

Liquid

1 mg/mL.

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Store at +4℃ after thawing. For long-term storage, please store it at -20℃. Avoid repeated freeze / thaw cycles.