TU399096

货号 规格 价格(¥)
TU399096S 50μl
TU399096M 100μl

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Note:  Application as IHC, only suitable for histochemical staining or fluorescence staining of paraffin-embedded sections. Application as ICC/IF, suitable for histochemical or fluorescent staining of frozen sections, as well as chemical and fluorescent staining at the cellular level.

注意:抗体应用为IHC的,抗体只适合于石蜡切片的组化染色或者荧光染色。

抗体应用为IF/ICC的,抗体适合于冰冻切片的组化染色或者荧光染色,以及细胞水平的化学染色和荧光染色。

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   免疫荧光

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   植物BPP法变性蛋白提取

   组织制备成单细胞悬液

经典一抗-CAMKIV antibody

Datasheet

Background

The Ca2+/calmodulin-dependent protein kinases (CaM kinases) comprise a structurally related subfamily of serine/threonine kinases which include CaMKI, CaMKII and CaMKIV. CaMKII is a ubiquitously expressed serine/threonine protein kinase that is activated by Ca2+and calmodulin (CaM) and has been implicated in regulation of the cell cycle and transcription. There are four CaMKII isozymes designated α, β, γ and δ, which may or may not be co-expressed in the same tissue type. CaMKIV is stimulated by Ca2+ and CaM but also requires phosphorylation by a CaMK for full activation. Stimulation of the T cell receptor CD3 signaling complex with an anti-CD3 monoclonal antibody leads to a 10-40 fold increase in CaMKIV activity. An additional kinase, CaMKK, functions to activate CaMKI through the specific phosphorylation of the regulatory Threonine residue at position 177.

Alternative Name

Calcium/calmodulin-dependent protein kinase type IV (CaMK IV) (EC 2.7.11.17) (CaM kinase-GR) CAMK4 CAMK CAMK-GR CAMKIV

Reactivity

Human,Mouse,Rat

Predicted Reactivity

Application

WB,IHC,IF,ICC,FC

Application Image

Recommended Dilution

WB 1:500-1:2000
IHC 1:50-1:200
IF 1:100-1:400
ICC 1:50-1:200
FC 1:50-1:100

Mol Weight

52 kDa

Gene Symbol

CAMK4 CAMK CAMK-GR CAMKIV

Uniprot

swissprot: q16566 human;swissprot: p08414 mouse;swissprot: p13234 rat

Uniprot link

Immunogen

Immunogen Range

Source

Rabbit

Clonality

Monoclonal

Isotype

Rabbit IgG

Specificity

Subcellular location

Research Area

Neuroscience->Neurotransmission->Calcium Signaling->Calmodulin / CaMK

Positive control

Mouse brain tissue lysate, rat brain tissue lysate, Hela, SH-SY5Y, 293T, human tonsil tissue, rat brain tissue, rat cerebellum tissue, mouse brain tissue.

Conjugation

Modification

Purification

Protein A affinity purified.

Formulation

Liquid

Concentration

1 mg/mL.

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

产品介绍

Clone

Target

波长

Storage

Store at +4℃ after thawing. For long-term storage, please store it at -20℃. Avoid repeated freeze / thaw cycles.

注意事项

Companion Products

Important

Comments

RRID

客户评价

艾比玛特医药科技(上海)有限公司
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      微信客服

邮箱:market@ab-mart.com

应聘职位:hr@ab-mart.com

订购专线:4006-123-828

销售电话:13916964679(微信同号)

技术支持:15618194176(微信同号)

华南经销商负责(广东,广西,福建,海南):
程经理:手机18616261485(微信同号)
华北经销商负责(北京,天津,河北):
徐经理:手机15618191473(微信同号)
南方经销商负责:

陆经理:手机13122837132(微信同号)
北方及西南经销商负责:

张经理:手机13122150513(微信同号)

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      微信客服

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