Signal transducer in the Ras-MAPK signaling pathway that regulates cell proliferation and survival (PubMed:16630891, PubMed:28289718, PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670). Core component of the SHOC2-MRAS-PP1c (SMP) holophosphatase complex that regulates the MAPK pathway activation (PubMed:16630891, PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670). The formation of the SMP complex only occurs when MRAS is GTP-bound (PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670). The SMP complex specifically dephosphorylates the inhibitory phosphorylation at ''Ser-259'' of RAF1 kinase, ''Ser-365'' of BRAF kinase and ''Ser-214'' of ARAF kinase, stimulating their kinase activities (PubMed:16630891, PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670).

Ras-related protein M-Ras (EC 3.6.5.2) (Ras-related protein R-Ras3)
MRAS RRAS3 M-RAs; R-RAS3; RRAS3

O14807

Human, Mouse, Rat

WB,IF,ICC,FC

WB 1:2000
IF 1:100
ICC 1:100-1:400
FC 1:100

23.7 kDa

Mouse

Full length human recombinant protein of human MRAS (NP_036351) produced in HEK293T cell.

Monoclonal

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Store at -20 °C. Stable for 12 months from date of receipt.