Transcription regulator required to maintain maternal and paternal gene imprinting, a process by which gene expression is restricted in a parent of origin-specific manner by epigenetic modification of genomic DNA and chromatin, including DNA methylation. Acts by controlling DNA methylation during the earliest multicellular stages of development at multiple imprinting control regions (ICRs) (PubMed:18622393, PubMed:30602440). Acts together with ZNF445, but ZNF445 seems to be the major factor in human early embryonic imprinting maintenance. In contrast, in mice, ZFP57 plays the predominant role in imprinting maintenance (PubMed:30602440). Required for the establishment of maternal methylation imprints at SNRPN locus. Acts as a transcriptional repressor in Schwann cells. Binds to a 5''-TGCCGC-3'' consensus sequence and recognizes the methylated CpG within this element (By similarity).

Zinc finger protein 57 homolog (Zfp-57) (Zinc finger protein 698)
ZFP57 C6orf40 ZNF698 bA145L22; bA145L22.2; C6orf40; TNDM1; ZNF698

Q9NU63

Human, Mouse

WB,IHC

WB 1:500-2000
IHC 1:2000

Mouse

Full length human recombinant protein of human ZFP57 (NP_001103279) produced in E.coli.

Monoclonal

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Store at -20 °C. Stable for 12 months from date of receipt.