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Note: Application as IHC, only suitable for histochemical staining or fluorescence staining of paraffin-embedded sections. Application as ICC/IF, suitable for histochemical or fluorescent staining of frozen sections, as well as chemical and fluorescent staining at the cellular level.
注意：抗体应用为IHC的，抗体只适合于石蜡切片的组化染色或者荧光染色。
抗体应用为IF/ICC的，抗体适合于冰冻切片的组化染色或者荧光染色，以及细胞水平的化学染色和荧光染色。
ABMART实验方案下载
Growth and Differentiation Factor 1 (GDF 1) is a secreted protein in the TGF beta superfamily (1). It is the functional equivalent of frog, zebrafish, and chick Vg1 (2, 3). Human GDF 1 is synthesized as a preproprotein that produces an approximately 44 kDa proprotein after cleavage of a 29 amino acid (aa) signal peptide. Further proteolysis at a dibasic cleavage site produces a 224 aa propeptide and a secreted 119 aa, 12 15 kDa mature peptide (4). Mature human GDF 1 shares 81% aa sequence identity with mouse and rat GDF 1. GDF 1 is expressed in the developing and adult nervous system, particularly in neurons of the cerebral cortex and hippocampus (4, 5). It is required during embryogenesis for development of left/right axis asymmetry, anterior/posterior axis asymmetry, and the notochord (2, 3, 6, 7). It cooperates with Nodal and GDF 3 in these activities and potentiates Nodal bioactivity through formation of a 27 kDa noncovalent GDF 1 Nodal heterodimer (3, 7, 8). The presence of Nodal is required for GDF 1 induced effects (8). GDF 1 signals through heteromeric receptor complexes containing Activin RIIA or Activin RIIB, ALK4 or ALK7, and an EGF CFC protein such as Cryptic or Cripto (7 9). Loss of function mutations in GDF 1 are associated with a variety of human cardiac development defects (10).
Embryonic growth/differentiation factor 1 (GDF-1) GDF1
Human
IHC
IHC 1:50-200
39/45kDa
2657
p27539
A synthetic peptide of human GDF1
90-140/372aa
Rabbit
Polyclonal
IgG
Secreted
Affinity purification
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
Store at -20℃. Avoid freeze / thaw cycles.
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订购专线：4006-123-828
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华南经销商负责（广东，广西，福建，海南）：
程经理：手机18616261485（微信同号）
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徐经理：手机15618191473（微信同号）
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陆经理：手机13122837132（微信同号）
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