Note: Application as IHC, only suitable for histochemical staining or fluorescence staining of paraffin-embedded sections. Application as ICC/IF, suitable for histochemical or fluorescent staining of frozen sections, as well as chemical and fluorescent staining at the cellular level.
注意:抗体应用为IHC的,抗体只适合于石蜡切片的组化染色或者荧光染色。
抗体应用为IF/ICC的,抗体适合于冰冻切片的组化染色或者荧光染色,以及细胞水平的化学染色和荧光染色。
ABMART实验方案下载
Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. Lamin A and C are present in equal amounts in the lamina of mammals. Play an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics.
Prelamin-A/C can accelerate smooth muscle cell senescence. It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence.
Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)] LMNA LMN1
Human
Monkey,Dog,Cat,Horse,Guinea Pig
WB,IHC,IF,ICC,IP,FC
WB 1:500-1:2000IHC 1:50-1:200IF 1:50-1:200ICC 1:50-1:200IP 1:50FC 1:50
63kDa/74kDa
LMNA LMN1
p02545
A synthesized peptide derived from human Lamin A/C
Rabbit
Monoclonal
Rabbit IgG
Lamin A/C Antibody detects endogenous levels of total Lamin A/C
Nucleus localization
Myogenesis
Affinity-chromatography
PBS, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
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