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Note: Application as IHC, only suitable for histochemical staining or fluorescence staining of paraffin-embedded sections. Application as ICC/IF, suitable for histochemical or fluorescent staining of frozen sections, as well as chemical and fluorescent staining at the cellular level.
注意：抗体应用为IHC的，抗体只适合于石蜡切片的组化染色或者荧光染色。
抗体应用为IF/ICC的，抗体适合于冰冻切片的组化染色或者荧光染色，以及细胞水平的化学染色和荧光染色。
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Component of a heteromeric calcium-permeable ion channel formed by PKD1 and PKD2 that is activated by interaction between PKD1 and a Wnt family member, such as WNT3A and WNT9B . Both PKD1 and PKD2 are required for channel activity . Involved in renal tubulogenesis . Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium (By similarity). Acts as a regulator of cilium length, together with PKD2 (By similarity). The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling (By similarity). The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling (By similarity). May be an ion-channel regulator. Involved in adhesive protein-protein and protein-carbohydrate interactions. Likely to be involved with polycystin-1-interacting protein 1 in the detection, sequestration and exocytosis of senescent mitochondria . .
Polycystin-1 (PC1) (Autosomal dominant polycystic kidney disease 1 protein) PKD1
Human
WB
WB 1:1000-1:2000
463kD
PKD1
P98161
Rabbit
Polyclonal
Rabbit IgG
Calcium transport #Chondrogenesis #anatomical structure morphogenesis, #calcium ion transmembrane transport
Product Information
| Description | Polycystin1rabbit polyclonal |
| Protein full name | Polycystin-1 |
Synonyms | PC1,Autosomal dominant polycystic kidney disease 1 protein,PKD1,PBP,PKD,PKD1,Polycystin 1 Precursor |
| Immunogen | RecombinantproteincorrespondingtoMousePolycystin 1 |
| Isotype | IgG |
| Purity | Affinity purification |
Predicted MW. | 463kDa |
Observed MW. | >460kDa |
| Uniprot ID |
Applications
| Applications | WB |
| Species | Human |
| Dilution | 1:500-1: 1000 |
| Positive tissue | HEK293, NIH/3t3, PC12, HCT116, SW480 |
Background
This gene encodes a member of the polycystin protein family. The encoded glycoprotein contains a large N-terminal extracellular region, multiple transmembrane domains and a cytoplasmic C-tail. It is an integral membrane protein that functions as a regulator of calcium permeable cation channels and intracellular calcium homoeostasis. It is also involved in cell-cell/matrix interactions and may modulate G-protein-coupled signal-transduction pathways. Involved in renal tubulogenesis. Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium (By similarity). Acts as a regulator of cilium length, together with PKD2 (By similarity). and mutations in this gene cause autosomal dominant polycystic kidney disease type 1 (ADPKD1). ADPKD1 is characterized by the growth of fluid-filled cysts that replace normal renal tissue and result in end-stage renal failure. Splice variants encoding different isoforms have been noted for this gene.
Images
 | Western blot analysis of Polycystin 1(T611019M) at dilution of 1: 800
Lane 1: HEK293 cell lysate Lane 2: NIH/3t3 cell lysate Lane 3: PC12 cell lysate Lane 4: HCT116 cell lysate Lane 5: SW480 cell lysate |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 mu;g/ml BSA and 50% glycerol. |
NOTE: This product is intended for research only.
Store at +4℃ after thawing. For long-term storage, please store it at -20℃. Avoid repeated freeze / thaw cycles.
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应聘职位：hr@ab-mart.com
订购专线：4006-123-828
销售电话：13916964679（微信同号）
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华南经销商负责（广东，广西，福建，海南）：
程经理：手机18616261485（微信同号）
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徐经理：手机15618191473（微信同号）
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