13916964679
Note: Application as IHC, only suitable for histochemical staining or fluorescence staining of paraffin-embedded sections. Application as ICC/IF, suitable for histochemical or fluorescent staining of frozen sections, as well as chemical and fluorescent staining at the cellular level.
注意：抗体应用为IHC的，抗体只适合于石蜡切片的组化染色或者荧光染色。
抗体应用为IF/ICC的，抗体适合于冰冻切片的组化染色或者荧光染色，以及细胞水平的化学染色和荧光染色。
ABMART实验方案下载
Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediator of PR-DUB complex component BAP1 nuclear import; acts redundantly with KPNA1 and Transportin-1/TNPO1 (By similarity). .
Importin subunit alpha-1 (Importin alpha P1) (Karyopherin subunit alpha-2) (Pendulin) (Pore targeting complex 58 kDa subunit) (PTAC58) (RAG cohort protein 1) (SRP1-alpha) Kpna2 Rch1
Rat,Mouse
WB,IHC,IF,ICC
WB 1:1000-1:2000IHC 1:50-1:200IF 1:100-1:400ICC 1:100-1:400
58kD
Kpna2 Rch1
P52293
Rabbit
Polyclonal
Rabbit IgG
Product Information
| Description | KPNA2 rabbit polyclonal |
| Protein full name | Importin subunit alpha-1 |
Synonyms | Importin alpha P1, Karyopherin subunit alpha-2, Pendulin, PTAC58, RAG cohort protein 1, SRP1-alpha, Kpna2, Rch1 |
| Immunogen | KLH conjugated Synthetic peptide corresponding to Mouse KPNA2 |
| Isotype | IgG |
| Purity | Affinity purification |
| Subcellular location | Cytoplasm,Nucleus |
Predicted MW. | 58 kDa |
Observed MW. | 58 kDa |
| Uniprot ID |
Applications
| Applications | WB | IHC | IF |
| Species | Mouse,Rat | Mouse,Rat | Mouse,Rat |
| Dilution | 1:500-1:1000 | 1:2000-1:3000 | 1:800-1:1600 |
| Positive tissue | testis, spleen, brain | brain, testis, liver, spleen | testis, bladder |
Background
KPNA2 (karyopherin alpha;2) is a nuclear import factor involved in the nucleocytoplasmic transport system. It is functionally involved in the tumor progression and is elevated in multiple cancers. KPNA2 expression may be a useful prognostic biomarker to monitor cancer prognosis.
Images
| Western blot analysis of KPNA2 (T611296M) at dilution of 1: 1000 |
| Immunohistochemistry analysis of paraffin-embedded mouse brain using KPNA2 (T611296M) at dilution of 1:2000 |
| Immunohistochemistry analysis of paraffin-embedded rat brainusing KPNA2 (T611296M) at dilution of 1:2000 |
| Immunohistochemistry analysis of paraffin-embedded mouse testisusing KPNA2 (T611296M) at dilution of 1:2000 |
| Immunohistochemistry analysis of paraffin-embedded rat testisusing KPNA2 (T611296M) at dilution of 1:2000 |
| Immunohistochemistry analysis of paraffin-embedded mouseliverusing KPNA2 (T611296M) at dilution of 1:2000 |
| Immunohistochemistry analysis of paraffin-embedded rat spleenusing KPNA2 (T611296M) at dilution of 1:2000 |
| Immunofluorescentanalysis ofparaformaldehyde-fixedmouse testis using KPNA2 (T611296M) at dilution of 1:800 |
| Immunofluorescentanalysis ofparaformaldehyde-fixedrat bladderusing KPNA2 (T611296M) at dilution of 1:800 |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 mu;g/ml BSA and 50% glycerol. |
NOTE: This product is intended for research only.
Store at +4℃ after thawing. For long-term storage, please store it at -20℃. Avoid repeated freeze / thaw cycles.
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邮箱：market@ab-mart.com
应聘职位：hr@ab-mart.com
订购专线：4006-123-828
销售电话：13916964679（微信同号）
技术支持：15618194176（微信同号）
华南经销商负责（广东，广西，福建，海南）：
程经理：手机18616261485（微信同号）
华北经销商负责（北京，天津，河北）：
徐经理：手机15618191473（微信同号）
南方经销商负责：
陆经理：手机13122837132（微信同号）
北方及西南经销商负责：
张经理：手机13122150513（微信同号）
微信客服
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