13916964679
Note: Application as IHC, only suitable for histochemical staining or fluorescence staining of paraffin-embedded sections. Application as ICC/IF, suitable for histochemical or fluorescent staining of frozen sections, as well as chemical and fluorescent staining at the cellular level.
注意：抗体应用为IHC的，抗体只适合于石蜡切片的组化染色或者荧光染色。
抗体应用为IF/ICC的，抗体适合于冰冻切片的组化染色或者荧光染色，以及细胞水平的化学染色和荧光染色。
ABMART实验方案下载
Catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. In addition to its cholesterol-synthesizing activity, can protect cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress. Also protects against amyloid-beta peptide-induced apoptosis. .
Delta(24)-sterol reductase (EC 1.3.1.72) (24-dehydrocholesterol reductase) (3-beta-hydroxysterol Delta-24-reductase) Dhcr24
Human,Rat,Mouse
IHC,IF,ICC
IHC 1:50-1:200IF 1:100-1:400ICC 1:100-1:400
61kD
Dhcr24
Q8VCH6,Q5BQE6
Rabbit
Polyclonal
Rabbit IgG
Cholesterol biosynthesis #Cholesterol metabolism #Steroid metabolism
Product Information
| Description | Seladin 1 rabbit polyclonal |
| Protein full name | Delta(24)-sterol reductase |
Synonyms | 24-dehydrocholesterol reductase, 3-beta-hydroxysterol Delta-24-reductase, Diminuto/dwarf1 homolog, Seladin-1, DHCR24, KIAA0018 |
| Immunogen | KLH conjugated Synthetic peptide corresponding to MouseSeladin 1 |
| Isotype | IgG |
| Purity | Affinity purification |
| Subcellular location | Cytoplasm |
| Uniprot ID |
Applications
| Applications | IHC | IF |
| Species | Mouse,Rat | Mouse,Rat |
| Dilution | 1:1500-1:3000 | 1:1500-1:3000 |
| Positive tissue | brain, spleen | brain, spinal cord |
Background
The Seladin 1encodes a flavin adenine dinucleotide (FAD)-dependent oxidoreductase which catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. Protects cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress. Also protects against amyloid-beta peptide-induced apoptosis.Missense mutations in this gene have been associated with desmosterolosis. Also, reduced expression of the gene occurs in the temporal cortex of Alzheimer disease patients and overexpression has been observed in adrenal gland cancer cells.
Images
| Immunohistochemistry analysis of paraffin-embedded mouse brain using Seladin 1 (T611301M) at dilution of 1:2600 |
| Immunohistochemistry analysis of paraffin-embedded rat brainusing Seladin 1 (T611301M) at dilution of 1:1500 |
| Immunohistochemistry analysis of paraffin-embedded mouse spleen using Seladin 1 (T611301M) at dilution of 1:1500 |
| Immunohistochemistry analysis of paraffin-embedded rat spleenusing Seladin 1 (T611301M) at dilution of 1:1500 |
| Immunofluorescentanalysis ofparaformaldehyde-fixedmouse brain using Seladin 1 (T611301M) at dilution of 1:1500 |
| Immunofluorescentanalysis ofparaformaldehyde-fixedrat spinal cordusing Seladin 1 (T611301M) at dilution of 1:2600 |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 mu;g/ml BSA and 50% glycerol. |
NOTE: This product is intended for research only.
Store at +4℃ after thawing. For long-term storage, please store it at -20℃. Avoid repeated freeze / thaw cycles.
艾比玛特医药科技（上海）有限公司
上海市徐汇区桂平路333号聚科生物园区1号楼1-3层
邮箱：market@ab-mart.com
应聘职位：hr@ab-mart.com
订购专线：4006-123-828
销售电话：13916964679（微信同号）
技术支持：15618194176（微信同号）
华南经销商负责（广东，广西，福建，海南）：
程经理：手机18616261485（微信同号）
华北经销商负责（北京，天津，河北）：
徐经理：手机15618191473（微信同号）
南方经销商负责：
陆经理：手机13122837132（微信同号）
北方及西南经销商负责：
张经理：手机13122150513（微信同号）
微信客服
邮箱：market@ab-mart.com
应聘职位：hr@ab-mart.com
订购专线：4006-123-828
销售电话：13916964679（微信同号）
技术支持：15618194176（微信同号）
华南经销商负责（广东，广西，福建，海南）：
程经理：手机18616261485（微信同号）
华北经销商负责（北京，天津，河北）：
徐经理：手机15618191473（微信同号）
南方经销商负责：
陆经理：手机13122837132（微信同号）
北方及西南经销商负责：
张经理：手机13122150513（微信同号）
微信客服
沪ICP备17056956号-2 艾比玛特医药科技（上海）有限公司
