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Note: Application as IHC, only suitable for histochemical staining or fluorescence staining of paraffin-embedded sections. Application as ICC/IF, suitable for histochemical or fluorescent staining of frozen sections, as well as chemical and fluorescent staining at the cellular level.
注意：抗体应用为IHC的，抗体只适合于石蜡切片的组化染色或者荧光染色。
抗体应用为IF/ICC的，抗体适合于冰冻切片的组化染色或者荧光染色，以及细胞水平的化学染色和荧光染色。
ABMART实验方案下载
Glycine receptors are ligand-gated chloride channels. GLRB does not form ligand-gated ion channels by itself, but is part of heteromeric ligand-gated chloride channels. Channel opening is triggered by extracellular glycine . Heteropentameric channels composed of GLRB and GLRA1 are activated by lower glycine levels than homopentameric GLRA1. Plays an important role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents (By similarity). .
Glycine receptor subunit beta (Glycine receptor 58 kDa subunit) Glrb
Rat,Mouse
IHC,IF,ICC
IHC 1:50-1:200IF 1:100-1:400ICC 1:100-1:400
56kD
Glrb
P48168,P20781
Rabbit
Polyclonal
Rabbit IgG
Ion transport #Neurogenesis #Vision #chemical synaptic transmission #neuropeptide signaling pathway
Product Information
| Description | GLRB rabbit polyclonal |
| Protein full name | Glycine receptor subunit beta |
| Synonyms | Glycine receptor 58 kDa subunit, Glrb, HKPX2, Glycine receptor subunit beta |
| Immunogen | Recombinantproteincorrespondingto Mouse GLRB |
| Isotype | IgG |
| Purity | Affinity purification |
| Subcellular location | Cell membrane |
| Uniprot ID | P48168, P20781 |
Applications
| Applications | Species | Dilution | Positive Tissue |
| IHC | Mouse,Rat | 1:500-1:1000 | brain |
| IF | Mouse,Rat | 1:500-1:1000 | brain, cerebellum |
Background
This gene encodes the beta subunit of the glycine receptor, which is a pentamer composed of alpha and beta subunits. The receptor functions as a neurotransmitter-gated ion channel, which produces hyperpolarization via increased chloride conductance due to the binding of glycine to the receptor. Glycine is an inhibitory neurotransmitter in the central nervous system. The glycine receptor (GlyR) is a member of the nicotinic acetylcholine receptor of ligand-gated ion channels. This receptor has important roles in a variety of physiological processes, especially in mediating inhibitory neurotransmission in the spinal cord and brain stem. Mutations in this gene cause startle disease, also known as hereditary hyperekplexia or congenital stiff-person syndrome, a disease characterized by muscular rigidity.
Images
 | Immunohistochemistry analysis of paraffin-embedded mouse brain usingGLRB (T611535M) at dilution of 1: 1000 |
 | Immunohistochemistry analysis of paraffin-embedded rat brain usingGLRB (T611535M) at dilution of 1: 1000 |
 | Immunofluorescent analysis of paraformaldehyde-fixed mouse brain usingGLRB (T611535M) at dilution of 1: 500 |
 | Immunofluorescent analysis of paraformaldehyde-fixed rat cerebellum using GLRB (T611535M) at dilution of 1: 500 |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 mu;g/ml BSA and 50% glycerol. |
NOTE: This product is intended for research only.
Store at +4℃ after thawing. For long-term storage, please store it at -20℃. Avoid repeated freeze / thaw cycles.
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应聘职位：hr@ab-mart.com
订购专线：4006-123-828
销售电话：13916964679（微信同号）
技术支持：15618194176（微信同号）
华南经销商负责（广东，广西，福建，海南）：
程经理：手机18616261485（微信同号）
华北经销商负责（北京，天津，河北）：
徐经理：手机15618191473（微信同号）
南方经销商负责：
陆经理：手机13122837132（微信同号）
北方及西南经销商负责：
张经理：手机13122150513（微信同号）
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