13916964679
Note: Application as IHC, only suitable for histochemical staining or fluorescence staining of paraffin-embedded sections. Application as ICC/IF, suitable for histochemical or fluorescent staining of frozen sections, as well as chemical and fluorescent staining at the cellular level.
注意：抗体应用为IHC的，抗体只适合于石蜡切片的组化染色或者荧光染色。
抗体应用为IF/ICC的，抗体适合于冰冻切片的组化染色或者荧光染色，以及细胞水平的化学染色和荧光染色。
ABMART实验方案下载
Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein. .
Cyclin-dependent kinase inhibitor 2A (Cyclin-dependent kinase 4 inhibitor A) (CDK4I) (Multiple tumor suppressor 1) (MTS-1) (p16-INK4a) (p16-INK4) (p16INK4A) CDKN2A CDKN2 MTS1
Human
WB
WB 1:1000-1:2000
17kD
CDKN2A CDKN2 MTS1
P42771
Rabbit
Polyclonal
Rabbit IgG
Cell cycle #Growth arrest
Product Information
| Description | CDKN2A/p16INK4arabbit polyclonal |
| Protein full name | Cyclin-dependent kinase inhibitor 2A |
| Synonyms | Cyclin-dependent kinase 4 inhibitor A, CDK4I,CDKN2A, MTS1, CDKN2 , Multiple tumor suppressor 1, MTS-1, p16-INK4a, p16INK4A, p16-INK4 |
| Immunogen | KLH conjugated Synthetic peptide corresponding to HumanCDKN2A/p16INK4a |
| Isotype | IgG |
| Purity | Affinity purification |
| Predicted MW. | 17 kDa |
| Observed MW. | 17kDa |
| Uniprot ID | P42771 |
Applications
| Applications | Species | Dilution | Positive Tissue |
| WB | Human | 1:500-1:1000 | Hela, Saso2, 293T, HepG2, HEK293 |
Background
This gene generates several transcript variants which differ in their first exons.There are at least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon and this transcript contains an alternate open reading frame (ARF) that ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene.
Images
 | Western blot analysis of CDKN2A/p16INK4 (T611605M) at dilution of 1: 1000 Lane 1: Hela cell lysate Lane 2: Saso2 cell lysate Lane 3: 293T cell lysate Lane 4: HepG2 cell lysate Lane 5: HEK293 cell lysate |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 mu;g/ml BSA and 50% glycerol. |
NOTE: This product is intended for research only.
Store at +4℃ after thawing. For long-term storage, please store it at -20℃. Avoid repeated freeze / thaw cycles.
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邮箱：market@ab-mart.com
应聘职位：hr@ab-mart.com
订购专线：4006-123-828
销售电话：13916964679（微信同号）
技术支持：15618194176（微信同号）
华南经销商负责（广东，广西，福建，海南）：
程经理：手机18616261485（微信同号）
华北经销商负责（北京，天津，河北）：
徐经理：手机15618191473（微信同号）
南方经销商负责：
陆经理：手机13122837132（微信同号）
北方及西南经销商负责：
张经理：手机13122150513（微信同号）
微信客服
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