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Note: Application as IHC, only suitable for histochemical staining or fluorescence staining of paraffin-embedded sections. Application as ICC/IF, suitable for histochemical or fluorescent staining of frozen sections, as well as chemical and fluorescent staining at the cellular level.
注意：抗体应用为IHC的，抗体只适合于石蜡切片的组化染色或者荧光染色。
抗体应用为IF/ICC的，抗体适合于冰冻切片的组化染色或者荧光染色，以及细胞水平的化学染色和荧光染色。
ABMART实验方案下载
[Gasdermin-C]: This form constitutes the precursor of the pore-forming protein: upon cleavage, the released N-terminal moiety (Gasdermin-C, N-terminal) binds to membranes and forms pores, triggering pyroptosis. .; [Gasdermin-C, N-terminal]: Pore-forming protein that causes membrane permeabilization and pyroptosis . Produced by the cleavage of gasdermin-C by caspase CASP8 in response to death signals . After cleavage, moves to the plasma membrane where it strongly binds to membrane inner leaflet lipids . Homooligomerizes within the membrane and forms pores of 10-15 nanometers (nm) of inner diameter, triggering pyroptosis . .
Gasdermin-C (Melanoma-derived leucine zipper-containing extranuclear factor) [Cleaved into: Gasdermin-C, N-terminal (GSDMC-NT); Gasdermin-C, C-terminal (GSDMC-CT)] GSDMC MLZE
Human,Rat,Mouse
WB
WB 1:1000-1:2000
58kD
GSDMC MLZE
Q9BYG8,Q99NB5,P85967
Rabbit
Polyclonal
Rabbit IgG
defense response to bacterium
Product Information
| Description | GSDMCrabbit polyclonal |
| Protein full name | Gasdermin-C |
| Synonyms | Gasdermin-C1, Melanoma-derived leucine zipper-containing extranuclear factor, mMLZE, Gsdmc, Gasdermin-C |
| Immunogen | KLH conjugated Synthetic peptide corresponding to Mouse GSDMC |
| Isotype | IgG |
| Purity | Affinity purification |
| Predicted MW. | 53 kDa |
| Observed MW. | 70kDa |
| Uniprot ID | Q9BYG8, Q99NB5, P85967 |
Applications
| Applications | Species | Dilution | Positive Tissue |
| WB | Human, Mouse, Rat | 1:500-1:1000 | skin, kidney |
Background
The N-terminal moiety promotes pyroptosis. May be acting by homooligomerizing within the membrane and forming pores. The physiological relevance of this observation is unknown.
Images
 | Western blot analysis of GSDMC (T611623M) at dilution of 1: 1000 Lane 1: C2C12 cell lysate Lane 2: PC12 cell lysate Lane 3: A431 cell lysate Lane 4: A375 cell tissue lysate Lane 5: Rat skin tissue lysate Lane 6: Rat kidney tissue lysate |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 mu;g/ml BSA and 50% glycerol. |
NOTE: This product is intended for research only.
Store at +4℃ after thawing. For long-term storage, please store it at -20℃. Avoid repeated freeze / thaw cycles.
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应聘职位：hr@ab-mart.com
订购专线：4006-123-828
销售电话：13916964679（微信同号）
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华南经销商负责（广东，广西，福建，海南）：
程经理：手机18616261485（微信同号）
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