13916964679
Note: Application as IHC, only suitable for histochemical staining or fluorescence staining of paraffin-embedded sections. Application as ICC/IF, suitable for histochemical or fluorescent staining of frozen sections, as well as chemical and fluorescent staining at the cellular level.
注意：抗体应用为IHC的，抗体只适合于石蜡切片的组化染色或者荧光染色。
抗体应用为IF/ICC的，抗体适合于冰冻切片的组化染色或者荧光染色，以及细胞水平的化学染色和荧光染色。
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Acts as a transcriptional repressor. Binds to E-box sequences in the immunoglobulin heavy chain enhancer as well as in the regulatory regions of many other tissue-specific genes. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1 (By similarity). Positively regulates neuronal differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding to the E box (5'-CANNTG-3'). In the absence of TGFB1, acts as a repressor of COL1A2 transcription via binding to the E-box in the upstream enhancer region . Promotes tumorigenicity by repressing stemness-inhibiting microRNAs . .
Zinc finger E-box-binding homeobox 1 (Delta EF1) (Transcription factor 8) (TCF-8) (Zinc finger homeobox protein 1a) (MEB1) Zeb1 Areb6 Tcf8 Zfhx1a Zfx1a Zfx1ha
Human,Rat,Mouse
IHC,IF,ICC
IHC 1:50-1:200IF 1:100-1:400ICC 1:100-1:400
123kD
Zeb1 Areb6 Tcf8 Zfhx1a Zfx1a Zfx1ha
Q64318
Rabbit
Polyclonal
Rabbit IgG
Chondrogenesis #Differentiation
Product Information
| Description | ZEB1 rabbit polyclonal |
| Protein full name | Zinc finger E-box-binding homeobox 1 |
| Synonyms | ZEB1,zinc finger E-box binding homeobox 1,AREB6,BZP,DELTAEF1,FECD6,NIL2A, PPCD3,TCF8,ZFHEP,ZFHX1A |
| Immunogen | Recombinantproteincorrespondingto Mouse ZEB1 |
| Isotype | IgG |
| Purity | Affinity purification |
| Subcellular location | Nucleus |
| Uniprot ID | Q64318 |
Applications
| applications | species | dilution | Positive tissue |
| IHC | Human, Mouse, Rat | 1:500-1:1000 | Tonsil,heart,lung |
| IF | Mouse, Rat | 1:500-1:1000 | brain, suckling mouse brain, fetal mouse brain, cerebellum, brain substantia nigra |
Background
Acts as a transcriptional repressor. Inhibits interleukin-2 (IL-2) gene expression. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Positively regulates neuronal differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding to the E box (5'-CANNTG-3'). Promotes tumorigenicity by repressing stemness-inhibiting microRNAs.
Images
 | Immunohistochemistry analysis of paraffin-embedded human tonsil using ZEB1 (T61513M) at dilution of 1:800. |
 | Immunohistochemistry analysis of paraffin-embedded mouse heart using ZEB1 (T61513M) at dilution of 1:800. |
 | Immunohistochemistry analysis of paraffin-embedded rat lung using ZEB1 (T61513M) at dilution of 1:800. |
 | Immunofluorescent analysis of paraformaldehyde-fixed mouse brain using ZEB1 (T61513M) at dilution of 1:1000. |
 | Immunofluorescent analysis of paraformaldehyde-fixed suckling mouse brain using ZEB1 (T61513M) at dilution of 1:500. |
 | Immunofluorescent analysis of paraformaldehyde-fixed fetal mouse brain using ZEB1 (T61513M) at dilution of 1:500. |
 | Immunofluorescent analysis of paraformaldehyde-fixed mouse cerebellum using ZEB1 (T61513M) at dilution of 1:500. |
 | Immunofluorescent analysis of paraformaldehyde-fixed rat brain substantia nigra using ZEB1 (T61513M) at dilution of 1:500. |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 mu;g/ml BSA and 50% glycerol. |
NOTE: This product is intended for research only.
Store at +4℃ after thawing. For long-term storage, please store it at -20℃. Avoid repeated freeze / thaw cycles.
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微信客服
邮箱：market@ab-mart.com
应聘职位：hr@ab-mart.com
订购专线：4006-123-828
销售电话：13916964679（微信同号）
技术支持：15618194176（微信同号）
华南经销商负责（广东，广西，福建，海南）：
程经理：手机18616261485（微信同号）
华北经销商负责（北京，天津，河北）：
徐经理：手机15618191473（微信同号）
南方经销商负责：
陆经理：手机13122837132（微信同号）
北方及西南经销商负责：
张经理：手机13122150513（微信同号）
微信客服
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