13916964679
Note: Application as IHC, only suitable for histochemical staining or fluorescence staining of paraffin-embedded sections. Application as ICC/IF, suitable for histochemical or fluorescent staining of frozen sections, as well as chemical and fluorescent staining at the cellular level.
注意：抗体应用为IHC的，抗体只适合于石蜡切片的组化染色或者荧光染色。
抗体应用为IF/ICC的，抗体适合于冰冻切片的组化染色或者荧光染色，以及细胞水平的化学染色和荧光染色。
ABMART实验方案下载
Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). In contrast to other components of the shelterin complex, it is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair. Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology-directed repair (HDR), which can affect telomere length. Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with TERF2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with TERF2 or other factors, and regulates gene expression. When cytoplasmic, associates with the I-kappa-B-kinase (IKK) complex and acts as a regulator of the NF-kappa-B signaling by promoting IKK-mediated phosphorylation of RELA/p65, leading to activate expression of NF-kappa-B target genes (By similarity). .
Telomeric repeat-binding factor 2-interacting protein 1 (TERF2-interacting telomeric protein 1) (TRF2-interacting telomeric protein 1) (Repressor/activator protein 1 homolog) (RAP1 homolog) Terf2ip Rap1
Human,Mouse
WB,IHC,IF,ICC
WB 1:1000-1:2000IHC 1:50-1:200IF 1:100-1:400ICC 1:100-1:400
44kD
Terf2ip Rap1
Q5EAN7
Rabbit
Polyclonal
Rabbit IgG
regulation of DNA-templated transcription,
Product Information
Description | RAP1 rabbit polyclonal |
Protein full name | Telomeric repeat-binding factor 2-interacting protein 1 |
Synonyms | TERF2IP, DRIP5, RAP1, TERF2 interacting protein |
Immunogen | Recombinantproteincorrespondingto Mouse RAP1 |
Isotype | IgG |
Purity | Affinity purification |
Subcellular location | |
Predicted MW. | 45 kDa |
Observed MW. | 46 kDa |
Uniprot ID |
Applications
applications | species | dilution | positive tissue |
WB | Human, Mouse | 1: 500-1: 1000 | spleen, thymus |
IHC | Rat | 1:1000-1:2000 | brain, lung |
IF | Rat | 1: 500-1: 1000 | brain, lung |
Background
Telomeric repeat-binding factor 2-interacting protein 1acts both as a regulator of telomere function and as a transcription regulator.it isinvolved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). In contrast to other components of the shelterin complex, it is dispensible for telomere capping and does not participate in the protection oftelomeres against non-homologous end-joining (NHEJ)-mediated repair. Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology-directed repair (HDR), which can affect telomere length.
Images
 | Western blot analysis of RAP1 (T61608M) at dilution of 1: 1000 Lane 1: A431 cell lysate Lane 2: Mouse spleen tissue lysate Lane 3: Mouse thymus tissue lysate |
 | Immunohistochemistry analysis of paraffin-embedded ratbrainusing RAP1 (T61608M) at dilution of 1:1000 |
 | Immunohistochemistry analysis of paraffin-embedded ratlung using RAP1 (T61608M) at dilution of 1:1000 |
| Immunofluorescentanalysis ofparaformaldehyde-fixedratimmune brain using RAP1 (T61608M) at dilution of 1:2000 |
| Immunofluorescentanalysis ofparaformaldehyde-fixedratspleen using RAP1 (T61608M) at dilution of 1:2000 |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 mu;g/ml BSA and 50% glycerol. |
NOTE: This product is intended for research only.
Store at +4℃ after thawing. For long-term storage, please store it at -20℃. Avoid repeated freeze / thaw cycles.
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邮箱：market@ab-mart.com
应聘职位：hr@ab-mart.com
订购专线：4006-123-828
销售电话：13916964679（微信同号）
技术支持：15618194176（微信同号）
华南经销商负责（广东，广西，福建，海南）：
程经理：手机18616261485（微信同号）
华北经销商负责（北京，天津，河北）：
徐经理：手机15618191473（微信同号）
南方经销商负责：
陆经理：手机13122837132（微信同号）
北方及西南经销商负责：
张经理：手机13122150513（微信同号）
微信客服
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