13916964679
Note: Application as IHC, only suitable for histochemical staining or fluorescence staining of paraffin-embedded sections. Application as ICC/IF, suitable for histochemical or fluorescent staining of frozen sections, as well as chemical and fluorescent staining at the cellular level.
注意：抗体应用为IHC的，抗体只适合于石蜡切片的组化染色或者荧光染色。
抗体应用为IF/ICC的，抗体适合于冰冻切片的组化染色或者荧光染色，以及细胞水平的化学染色和荧光染色。
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Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor . Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system . .
C-X-C chemokine receptor type 1 (CXC-R1) (CXCR-1) (CDw128a) (High affinity interleukin-8 receptor A) (IL-8R A) (IL-8 receptor type 1) (CD antigen CD181) CXCR1 CMKAR1 IL8RA
Human,Rat,Mouse
WB,IHC,IF,ICC
WB 1:1000-1:2000IHC 1:50-1:200IF 1:100-1:400ICC 1:100-1:400
40kD
CXCR1 CMKAR1 IL8RA
P25024,Q810W6,P70612
Rabbit
Polyclonal
Rabbit IgG
G protein-coupled receptor signaling pathway
Product Information
Description | CXCR1 rabbit polyclonal |
Protein full name | C-X-C chemokine receptor type 1 |
Synonyms | CXCR1, C-C, C-C-CKR-1, CD128, CD181, CDw128a, CKR-1, CMKAR1, IL8R1, IL8RA, IL8RBA, Interleukin 8 receptor, C-X-C motif chemokine receptor 1 |
Immunogen | KLH conjugated Synthetic peptide corresponding to MouseCXCR1 |
Isotype | IgG |
Purity | Affinity purification |
Subcellular location | |
Predicted MW. | 40 kDa |
Observed MW. | 45 kDa |
Uniprot ID |
Applications
Applications | Species | Dilution | Positive Tissue |
WB | Human,Mouse,Rat | 1:500-1:1000 | pneumonia, splenitis |
IHC | Human,Mouse,Rat | 1: 1000-1: 2000 | spleen，immune spleen |
IF | Human,Mouse,Rat | 1: 500-1: 1000 | spleen，immune spleen |
Background
CXCR1 is a chemokine receptor, which is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein-activated second messenger system. Knockout studies in mice suggested that this protein inhibits embryonic oligodendrocyte precursor migration in developing spinal cord. Stimulation of CXCR1 in neutrophils by its primary ligand, Interleukin 8, leads to neutrophil chemotaxis and activation.
Images
 | Western blot analysis of CXCR1 (T61625M) at dilution of 1: 1000 Lane 1: HeLa cell lysate Lane 2: HepG2 cell lysate Lane 3: Jurkat cell lysate Lane 4: A20 cell lysate Lane 5: Raw264.7 cell lysate Lane 6: Mouse splenitis tissue lysate Lane 7: Mouse pneumonia tissue lysate Lane 8: Rat splenitis tissue lysate Lane 9: Rat pneumonia tissue lysate |
 | Immunohistochemistry analysis of paraffin-embedded mouse spleen using CXCR1 (T61625M) at dilution of 1: 1000 |
 | Immunohistochemistry analysis of paraffin-embedded mouse immune spleen using CXCR1 (T61625M) at dilution of 1: 1000 |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 mu;g/ml BSA and 50% glycerol. |
NOTE: This product is intended for research only.
Store at +4℃ after thawing. For long-term storage, please store it at -20℃. Avoid repeated freeze / thaw cycles.
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邮箱：market@ab-mart.com
应聘职位：hr@ab-mart.com
订购专线：4006-123-828
销售电话：13916964679（微信同号）
技术支持：15618194176（微信同号）
华南经销商负责（广东，广西，福建，海南）：
程经理：手机18616261485（微信同号）
华北经销商负责（北京，天津，河北）：
徐经理：手机15618191473（微信同号）
南方经销商负责：
陆经理：手机13122837132（微信同号）
北方及西南经销商负责：
张经理：手机13122150513（微信同号）
微信客服
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