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Note: Application as IHC, only suitable for histochemical staining or fluorescence staining of paraffin-embedded sections. Application as ICC/IF, suitable for histochemical or fluorescent staining of frozen sections, as well as chemical and fluorescent staining at the cellular level.
注意：抗体应用为IHC的，抗体只适合于石蜡切片的组化染色或者荧光染色。
抗体应用为IF/ICC的，抗体适合于冰冻切片的组化染色或者荧光染色，以及细胞水平的化学染色和荧光染色。
ABMART实验方案下载
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. Plays an important role in the regulation of synaptic plasticity and the modulation of the neural network activity. .
Metabotropic glutamate receptor 5 (mGluR5) Grm5 Gprc1e Mglur5
Human
WB
WB 1:1000-1:2000
132kD
Grm5 Gprc1e Mglur5
Q3UVX5,P31424
Rabbit
Polyclonal
Rabbit IgG
chemical synaptic transmission
Product Information
Description | Metabotropic Glutamate Receptor 5 rabbit polyclonal |
Protein full name | Metabotropic glutamate receptor 5 |
Synonyms | Grm5, Metabotropic Glutamate Receptor 5, GRM5, GPRC1E, MGLUR5, PPP1R86, MGlu5 |
Immunogen | KLH conjugated Synthetic peptide corresponding to Human Metabotropic Glutamate Receptor 5 |
Isotype | IgG |
Purity | Affinity purification |
Predicted MW. | 128 kDa |
Observed MW. | 128 kDa |
Uniprot ID |
Applications
Applications | Species | Dilution | Positive Tissue |
WB | Human | 1:500-1:1000 | HeLa, SH-SY5Y |
Background
The amino acid L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacological properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7, and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.
Images
 | Western blot analysis of Metabotropic Glutamate Receptor 5 (T61746M) at dilution of 1: 1000 Lane 1: HeLa cell lysate Lane 2: SH-SY5Y cell lysate |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 mu;g/ml BSA and 50% glycerol. |
NOTE: This product is intended for research only.
Store at +4℃ after thawing. For long-term storage, please store it at -20℃. Avoid repeated freeze / thaw cycles.
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应聘职位：hr@ab-mart.com
订购专线：4006-123-828
销售电话：13916964679（微信同号）
技术支持：15618194176（微信同号）
华南经销商负责（广东，广西，福建，海南）：
程经理：手机18616261485（微信同号）
华北经销商负责（北京，天津，河北）：
徐经理：手机15618191473（微信同号）
南方经销商负责：
陆经理：手机13122837132（微信同号）
北方及西南经销商负责：
张经理：手机13122150513（微信同号）
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