13916964679
Note: Application as IHC, only suitable for histochemical staining or fluorescence staining of paraffin-embedded sections. Application as ICC/IF, suitable for histochemical or fluorescent staining of frozen sections, as well as chemical and fluorescent staining at the cellular level.
注意：抗体应用为IHC的，抗体只适合于石蜡切片的组化染色或者荧光染色。
抗体应用为IF/ICC的，抗体适合于冰冻切片的组化染色或者荧光染色，以及细胞水平的化学染色和荧光染色。
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Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex. Acts both as a positive and negative regulator of the Wnt signaling pathway, depending on the context: acts as a positive regulator by promoting LRP6 phosphorylation. Also acts as a negative regulator by acting as a scaffold protein for the beta-catenin destruction complex and promoting stabilization of Axin at the cell membrane. Promotes CTNNB1 ubiquitination and degradation. Involved in kidney development. .
APC membrane recruitment protein 1 (Amer1) (Protein FAM123B) (Wilms tumor gene on the X chromosome protein) AMER1 FAM123B WTX
Human,Rat,Mouse
WB
WB 1:1000-1:2000
125kD
AMER1 FAM123B WTX
Q5JTC6,Q7TS75
Rabbit
Polyclonal
Rabbit IgG
Wnt signaling pathway
Product Information
| Description | FAM123B rabbit polyclonal |
| Protein full name | APC membrane recruitment protein 1 |
Synonyms | Amer1, AMER1, wtx, OSCS, Wilms tumor gene on the X chromosome protein, Wilms tumor on the X, WTX |
| Immunogen | RecombinantproteincorrespondingtoMouse FAM123B |
| Isotype | IgG |
| Purity | Affinity purification |
Predicted MW. | 125 kDa |
Observed MW. | 125 kDa |
| Uniprot ID |
Applications
| Applications | WB | ||
| Species | Human,Mouse,Rat | ||
| Dilution | 1:500-1:1000 | ||
| Positive tissue | kidney, brain, lung |
Background
Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex. Acts both as a positive and negative regulator of the Wnt signaling pathway, depending on the context: acts as a positive regulator by promoting LRP6 phosphorylation.Also acts as a negative regulator by acting as a scaffold protein for the beta-catenin destruction complex and promoting stabilization of Axin at the cell membrane. Promotes CTNNB1 ubiquitination and degradation. Involved in kidney development.
Images
 | Western blot analysis of FAM123B (T61816M) at dilution of 1: 1000 Lane 1: Mouse kidney tissue lysate Lane 2: Mouse brain tissue lysate Lane 3: Mouse lung tissue lysate Lane 4: Rat kidney tissue lysate Lane 5: Rat brain tissue lysate |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 mu;g/ml BSA and 50% glycerol. |
NOTE: This product is intended for research only.
Store at +4℃ after thawing. For long-term storage, please store it at -20℃. Avoid repeated freeze / thaw cycles.
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邮箱：market@ab-mart.com
应聘职位：hr@ab-mart.com
订购专线：4006-123-828
销售电话：13916964679（微信同号）
技术支持：15618194176（微信同号）
华南经销商负责（广东，广西，福建，海南）：
程经理：手机18616261485（微信同号）
华北经销商负责（北京，天津，河北）：
徐经理：手机15618191473（微信同号）
南方经销商负责：
陆经理：手机13122837132（微信同号）
北方及西南经销商负责：
张经理：手机13122150513（微信同号）
微信客服
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