13916964679
Note: Application as IHC, only suitable for histochemical staining or fluorescence staining of paraffin-embedded sections. Application as ICC/IF, suitable for histochemical or fluorescent staining of frozen sections, as well as chemical and fluorescent staining at the cellular level.
注意：抗体应用为IHC的，抗体只适合于石蜡切片的组化染色或者荧光染色。
抗体应用为IF/ICC的，抗体适合于冰冻切片的组化染色或者荧光染色，以及细胞水平的化学染色和荧光染色。
ABMART实验方案下载
Receptor for the C-X3-C chemokine fractalkine (CX3CL1) present on many early leukocyte cells; CX3CR1-CX3CL1 signaling exerts distinct functions in different tissue compartments, such as immune response, inflammation, cell adhesion and chemotaxis. CX3CR1-CX3CL1 signaling mediates cell migratory functions. Responsible for the recruitment of natural killer (NK) cells to inflamed tissues. Acts as a regulator of inflammation process leading to atherogenesis by mediating macrophage and monocyte recruitment to inflamed atherosclerotic plaques, promoting cell survival. Involved in airway inflammation by promoting interleukin 2-producing T helper (Th2) cell survival in inflamed lung. Involved in the migration of circulating monocytes to non-inflamed tissues, where they differentiate into macrophages and dendritic cells. Acts as a negative regulator of angiogenesis, probably by promoting macrophage chemotaxis. Plays a key role in brain microglia by regulating inflammatory response in the central nervous system (CNS) and regulating synapse maturation. Required to restrain the microglial inflammatory response in the CNS and the resulting parenchymal damage in response to pathological stimuli. Involved in brain development by participating in synaptic pruning, a natural process during which brain microglia eliminates extra synapses during postnatal development. Synaptic pruning by microglia is required to promote the maturation of circuit connectivity during brain development. Acts as an important regulator of the gut microbiota by controlling immunity to intestinal bacteria and fungi. Expressed in lamina propria dendritic cells in the small intestine, which form transepithelial dendrites capable of taking up bacteria in order to provide defense against pathogenic bacteria. Required to initiate innate and adaptive immune responses against dissemination of commensal fungi (mycobiota) component of the gut: expressed in mononuclear phagocytes (MNPs) and acts by promoting induction of antifungal IgG antibodies response to confer protection against disseminated C.albicans or C.auris infection (By similarity). Also acts as a receptor for C-C motif chemokine CCL26, inducing cell chemotaxis (By similarity). .
CX3C chemokine receptor 1 (C-X3-C CKR-1) (CX3CR1) (Fractalkine receptor) Cx3cr1 Rbs11
Rat,Mouse
IHC,IF,ICC
IHC 1:50-1:200IF 1:100-1:400ICC 1:100-1:400
41kD
Cx3cr1 Rbs11
Q9Z0D9,P35411
Rabbit
Polyclonal
Rabbit IgG
Adaptive immunity #Cell adhesion #Chemotaxis
Product Information
| Description | CX3CR1 rabbit polyclonal |
| Protein full name | CX3C chemokine receptor 1 |
Synonyms | Cx3cr1, CX3CR1, CCRL1, CMKBRL1, CMKDR1, GPR13, GPRV28, V28, C-X3-C motif chemokine receptor 1 |
| Immunogen | KLH conjugated Synthetic peptidecorresponding to MouseCX3CR1 |
| Isotype | IgG |
| Purity | Affinity purification |
| Subcellular location | Cell membrane |
| Uniprot ID |
Applications
| Applications | IHC | IF | |
| Species | Mouse,Rat | Mouse,Rat | |
| Dilution | 1:2000-1:4000 | 1:1000-1:2000 | |
| Positive tissue | lung, pneumonia,hepatitis, spleen | lung, pneumonia,hepatitis, spleen |
Background
Fractalkine is a transmembrane protein and chemokine involved in the adhesion and migration of leukocytes. The protein encoded by this gene is a receptor for fractalkine. The encoded protein also is a coreceptor for HIV-1, and some variations in this gene lead to increased susceptibility to HIV-1 infection and rapid progression to AIDS. Four transcript variants encoding two different isoforms have been found for this gene.
Images
 | Immunohistochemistry analysis of paraffin-embedded mouse lungusingCX3CR1 (T61861M) at dilution of 1:3000 | |
 | Immunohistochemistry analysis of paraffin-embedded mouse pneumonia usingCX3CR1 (T61861M) at dilution of 1:3000 | |
 | Immunohistochemistry analysis of paraffin-embedded rat lungusingCX3CR1 (T61861M) at dilution of 1:3000 | |
 | Immunohistochemistry analysis of paraffin-embedded rat pneumoniausingCX3CR1 (T61861M) at dilution of 1:3000 | |
 | Immunohistochemistry analysis of paraffin-embedded rat hepatitisusingCX3CR1 (T61861M) at dilution of 1:3000 | |
 | Immunohistochemistry analysis of paraffin-embedded rat spleenusingCX3CR1 (T61861M) at dilution of 1:3000 |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 mu;g/ml BSA and 50% glycerol. |
NOTE: This product is intended for research only.
Store at +4℃ after thawing. For long-term storage, please store it at -20℃. Avoid repeated freeze / thaw cycles.
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邮箱：market@ab-mart.com
应聘职位：hr@ab-mart.com
订购专线：4006-123-828
销售电话：13916964679（微信同号）
技术支持：15618194176（微信同号）
华南经销商负责（广东，广西，福建，海南）：
程经理：手机18616261485（微信同号）
华北经销商负责（北京，天津，河北）：
徐经理：手机15618191473（微信同号）
南方经销商负责：
陆经理：手机13122837132（微信同号）
北方及西南经销商负责：
张经理：手机13122150513（微信同号）
微信客服
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