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Note: Application as IHC, only suitable for histochemical staining or fluorescence staining of paraffin-embedded sections. Application as ICC/IF, suitable for histochemical or fluorescent staining of frozen sections, as well as chemical and fluorescent staining at the cellular level.
注意：抗体应用为IHC的，抗体只适合于石蜡切片的组化染色或者荧光染色。
抗体应用为IF/ICC的，抗体适合于冰冻切片的组化染色或者荧光染色，以及细胞水平的化学染色和荧光染色。
ABMART实验方案下载
Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Binds RNA in vitro. May be involved in RNA metabolism. In concert with CIC and ATXN1L, involved brain development. .
Ataxin-1 (Spinocerebellar ataxia type 1 protein homolog) Atxn1 Sca1
Human
WB,IHC,IF,ICC
WB 1:1000-1:2000IHC 1:50-1:200IF 1:100-1:400ICC 1:100-1:400
84kD
Atxn1 Sca1
P54254,Q63540
Rabbit
Polyclonal
Rabbit IgG
Neurogenesis #phosphorylation
Product Information
| Description | Ataxin 1rabbit polyclonal |
| Protein full name | Ataxin-1 |
Synonyms | Spinocerebellar ataxia type 1 protein homolog, Atxn1, Sca1, SCA1D6S504E |
| Immunogen | RecombinantproteincorrespondingtoMouse Ataxin 1 |
| Isotype | IgG |
| Purity | Affinity purification |
| Subcellular location | Cytoplasm,Nucleus |
Predicted MW. | 84 kDa |
| Observed MW. | 100 kDa |
| Uniprot ID | P54254,Q63540 |
Applications
| Applications | WB | IHC | IF |
| Species | Human | Mouse,Rat | Mouse,Rat |
| Dilution | 1:500-1:1000 | 1:500-1:1500 | 1:250-1:1000 |
| Positive tissue | SH-SY5Y, U87, U251 | lung, brain | lung, brain |
Background
Defects in ATXN1 are the cause of spinocerebellar ataxia type 1(SCA1) ;also known as olivopontocerebellar atrophy I(OPCA I or OPCA1). Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to cerebellum degeneration with variable involvement of the brainstem and spinal cord. SCA1 belongs to the autosomal dominant cerebellar ataxias type I(ADCA I) which are characterized by cerebellar ataxia in combination with additional clinical features like optic atrophy,ophthalmoplegia,bulbar and extrapyramidal signs, peripheral neuropathy and dementia. SCA1 is caused by expansion of a CAG repeat in the coding region of ATXN1. Longer expansions result in earlier onset and more severe clinical manifestations of the disease.
Images
 | Western blot analysis of Ataxin 1(T61988M)at dilution of 1: 1000 Lane 1: SH-SY5Y cell lysate Lane 2: U87 cell lysate Lane 3: U251 cell lysate | |
 | Immunohistochemistry analysis of paraffin-embedded mouse lung usingAtaxin 1 (T61988M) at dilution of 1: 1000 | |
 | Immunohistochemistry analysis of paraffin-embedded rat lung usingAtaxin 1 (T61988M) at dilution of 1: 1000 | |
 | Immunohistochemistry analysis of paraffin-embedded suckling mice brain using Ataxin 1 (T61988M) at dilution of 1: 1000 | |
 | Immunohistochemistry analysis of paraffin-embedded rat brain usingAtaxin 1 (T61988M) at dilution of 1: 1000 |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 mu;g/ml BSA and 50% glycerol. |
NOTE: This product is intended for research only.
Store at +4℃ after thawing. For long-term storage, please store it at -20℃. Avoid repeated freeze / thaw cycles.
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邮箱：market@ab-mart.com
应聘职位：hr@ab-mart.com
订购专线：4006-123-828
销售电话：13916964679（微信同号）
技术支持：15618194176（微信同号）
华南经销商负责（广东，广西，福建，海南）：
程经理：手机18616261485（微信同号）
华北经销商负责（北京，天津，河北）：
徐经理：手机15618191473（微信同号）
南方经销商负责：
陆经理：手机13122837132（微信同号）
北方及西南经销商负责：
张经理：手机13122150513（微信同号）
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