13916964679
Note: Application as IHC, only suitable for histochemical staining or fluorescence staining of paraffin-embedded sections. Application as ICC/IF, suitable for histochemical or fluorescent staining of frozen sections, as well as chemical and fluorescent staining at the cellular level.
注意：抗体应用为IHC的，抗体只适合于石蜡切片的组化染色或者荧光染色。
抗体应用为IF/ICC的，抗体适合于冰冻切片的组化染色或者荧光染色，以及细胞水平的化学染色和荧光染色。
ABMART实验方案下载
Non-catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth . The TSC-TBC complex acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 . In absence of nutrients, the TSC-TBC complex inhibits mTORC1, thereby preventing phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) by the mTORC1 signaling . The TSC-TBC complex is inactivated in response to nutrients, relieving inhibition of mTORC1 . .
TBC1 domain family member 7 (Cell migration-inducing protein 23) TBC1D7 TBC7 HSPC239
Human,Rat,Mouse
WB
WB 1:1000-1:2000
34kD
TBC1D7 TBC7 HSPC239
Q9P0N9,Q9D0K0,D4AAY4
Rabbit
Polyclonal
Rabbit IgG
Product Information
| Description | TBC1D7rabbit polyclonal |
| Protein full name | TBC1 domain family member 7 |
Synonyms | Tbc1d7, cell migration-inducing protein 23, dJ257A7.3, DKFZp686N2317, FLJ32666, PIG51, TBC1 domain family member 7, TBC7, TCD1D7 |
| Immunogen | RecombinantproteincorrespondingtoMouse TBC1D7 |
| Isotype | IgG |
| Purity | Affinity purification |
Predicted MW. | 34 kDa |
| Observed MW. | 36 kDa |
| Uniprot ID |
Applications
| Applications | WB |
| Species | Human,Mouse,Rat |
| Dilution | 1:500-1:1000 |
| Positive tissue | prostate, testis, brain |
Background
TBC1 domain family member 7 (TBC1D7, TBC7) belongs to a family of TBC (Tre-2/Bub2/Cdc16) containing proteins that function as GTPase-activating proteins (GAPs) . TBC1D7 was initially identified as a novel binding protein within the TSC1-TSC2 complex, where it was thought to associate with TSC1 . Additional research indicates that TBC1D7 is a third subunit of the TSC1-TSC2 complex that possesses Rheb-GAP activity and signals upstream of mTORC1. Knockdown of TBC1D7 limits the association between TSC1 and TSC2, resulting in reduced Rheb-GAP activity and increased mTORC1 signaling . Mutations in the corresponding TBC1D7 gene result in increased mTORC1 signaling, delayed autophagy, and are associated with intellectual disability (ID) and macrocrania.
Images
 | Western blot analysis of TBC1D7(T61990M) at dilution of 1: 1000 Lane 1: Hela cell lysate Lane 2: K562 cell lysate Lane 3: NIH3T3 cell lysate Lane 4: Mouse prostate tissue lysate Lane 5: Mouse testis tissue lysate Lane 6: Mouse brain tissue lysate Lane 7: Rat prostate tissue lysate Lane 8: Rat testis tissue lysate Lane 9: Rat brain tissue lysate |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 mu;g/ml BSA and 50% glycerol. |
NOTE: This product is intended for research only.
Store at +4℃ after thawing. For long-term storage, please store it at -20℃. Avoid repeated freeze / thaw cycles.
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邮箱：market@ab-mart.com
应聘职位：hr@ab-mart.com
订购专线：4006-123-828
销售电话：13916964679（微信同号）
技术支持：15618194176（微信同号）
华南经销商负责（广东，广西，福建，海南）：
程经理：手机18616261485（微信同号）
华北经销商负责（北京，天津，河北）：
徐经理：手机15618191473（微信同号）
南方经销商负责：
陆经理：手机13122837132（微信同号）
北方及西南经销商负责：
张经理：手机13122150513（微信同号）
微信客服
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