Note: Application as IHC, only suitable for histochemical staining or fluorescence staining of paraffin-embedded sections. Application as ICC/IF, suitable for histochemical or fluorescent staining of frozen sections, as well as chemical and fluorescent staining at the cellular level.
注意:抗体应用为IHC的,抗体只适合于石蜡切片的组化染色或者荧光染色。
抗体应用为IF/ICC的,抗体适合于冰冻切片的组化染色或者荧光染色,以及细胞水平的化学染色和荧光染色。
ABMART实验方案下载
Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RPA2, SMC1 and p53/TP53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis. Phosphorylates 'Ser-139' of histone variant H2AX at sites of DNA damage, thereby regulating DNA damage response mechanism. Required for FANCD2 ubiquitination. Critical for maintenance of fragile site stability and efficient regulation of centrosome duplication.
Serine/threonine-protein kinase ATR (EC 2.7.11.1) (Ataxia telangiectasia and Rad3-related protein) (FRAP-related protein 1) ATR FRP1
Human, Mouse
Bovine, Sheep
WB,IF,ICC
WB 1:500-1:2000IF 1:50-1:500ICC 1:50-1:500
300kD; 301kDa(Calculated).
ATR FRP1
q13535
Rabbit
Polyclonal
Rabbit IgG
Phospho-ATR (Thr1989) Antibody detects endogenous levels of ATR only when phosphorylated at Thr1989.
Nucleus localization
DNA damage #DNA excision #DNA replication #negative regulation of DNA replication
PBS,pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
Store at -20 °C. Stable for 12 months from date of receipt.
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