Note: Application as IHC, only suitable for histochemical staining or fluorescence staining of paraffin-embedded sections. Application as ICC/IF, suitable for histochemical or fluorescent staining of frozen sections, as well as chemical and fluorescent staining at the cellular level.
注意:抗体应用为IHC的,抗体只适合于石蜡切片的组化染色或者荧光染色。
抗体应用为IF/ICC的,抗体适合于冰冻切片的组化染色或者荧光染色,以及细胞水平的化学染色和荧光染色。
ABMART实验方案下载
Mediates interferon-stimulated response element (ISRE) promoter activation. Functions as a molecular switch for antiviral activity. DsRNA generated during the course of an viral infection leads to IRF3 phosphorylation on the C-terminal serine/threonine cluster. This induces a conformational change, leading to its dimerization, nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of genes under the control of ISRE.
Interferon regulatory factor 3 (IRF-3) IRF3
Human
WB,IF,ICC
WB 1:1000-1:2000IF 1:50-1:200ICC 1:50-1:200
47kDa
IRF3
q14653
A synthesized peptide derived from human Phospho-IRF3 (S386)
Rabbit
Monoclonal
Rabbit IgG
Phospho-IRF3 (S386) Antibody detects endogenous levels of total Phospho-IRF3 (S386)
Apoptosis #Antiviral defense #DNA damage #Immunity
Affinity-chromatography
PBS, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
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