13916964679
Note: Application as IHC, only suitable for histochemical staining or fluorescence staining of paraffin-embedded sections. Application as ICC/IF, suitable for histochemical or fluorescent staining of frozen sections, as well as chemical and fluorescent staining at the cellular level.
注意：抗体应用为IHC的，抗体只适合于石蜡切片的组化染色或者荧光染色。
抗体应用为IF/ICC的，抗体适合于冰冻切片的组化染色或者荧光染色，以及细胞水平的化学染色和荧光染色。
ABMART实验方案下载
METTL11A, also named N terminal RCC1 methyltransferase (NRMT), is an alpha N methyltransferase that methylates the N terminal amino group of target proteins containing the N terminal motif [Ala/Pro/Ser]-Pro-Lys when the initiator Met is cleaved (1). It is responsible for N terminal methylation of RCC1, KLHL31, MYL2, MYL3, RB1, RPL23A and SET. NRMT lacks a SET domain but possesses a Rossman like a/b fold. The residues Asn169, Asp178, Asp181, and Ser183 of NRMT are important for substrate binding (2). RCC1 (Ran guanine nucleotide exchange factor) is the first protein for which any biological function of alpha N methylation by NRMT has been identified (3, 4). The multi spindle phenotype associated with either NRMT knockdown or methylation defective RCC1 mutants demonstrated the importance of alpha N methylation of RCC1 for normal bipolar spindle formation and chromosome aggregation (2). NRMT is robustly overexpressed in gastrointestinal cancers.
N-terminal Xaa-Pro-Lys N-methyltransferase 1 (EC 2.1.1.244) (Alpha N-terminal protein methyltransferase 1A) (Methyltransferase-like protein 11A) (N-terminal RCC1 methyltransferase) (X-Pro-Lys N-terminal protein methyltransferase 1A) (NTM1A) [Cleaved into: N-terminal Xaa-Pro-Lys N-methyltransferase 1, N-terminally processed] NTMT1 C9orf32 METTL11A NRMT NRMT1 AD-003
Human;Mouse;Rat
Bovine;Zebrafish
WB,IHC
WB 1:1000-3000IHC 1:50-200
16/25kDa
28989
q9bv86
Recombinant protein of human NTMT1
1-224aa
Rabbit
Polyclonal
IgG
Cytoplasm Nucleus
Chromosome partition
Affinity purification
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
Store at -20℃. Avoid freeze / thaw cycles.
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程经理：手机18616261485（微信同号）
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徐经理：手机15618191473（微信同号）
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