13916964679
Note: Application as IHC, only suitable for histochemical staining or fluorescence staining of paraffin-embedded sections. Application as ICC/IF, suitable for histochemical or fluorescent staining of frozen sections, as well as chemical and fluorescent staining at the cellular level.
注意：抗体应用为IHC的，抗体只适合于石蜡切片的组化染色或者荧光染色。
抗体应用为IF/ICC的，抗体适合于冰冻切片的组化染色或者荧光染色，以及细胞水平的化学染色和荧光染色。
ABMART实验方案下载
Protein Wnt-8a is a protein that in humans is encoded by the WNT8A gene. Wnt8a may be involved in the development of early embryos as well as germ cell tumors. The Wnt8a gene is part of the Wnt family of genes and plays a role in vertebrates in the process of axis patterning. Wnt8a encodes for 2 proteins, Wnt8a.1 and Wnt8a.2 via a complicated mechanism involving the coordination of signaling molecules to control up and down stream promoters. Furthermore, Wnt8a has shown to play a role in neural crest induction via Wnt/β-catenin signaling based on experiments using zebrafish as a model organism. Wnt8a among other Wnt genes influence the Wnt/β-catenin signaling in neural crest development. β-catenin is degraded in the absence of a Wnt signaling, but upon the binding of a Wnt ligand with a frizzled receptor and Lrp5/6 the β-catenin signaling molecule is no longer degraded. Instead, it interacts with transcription factors that activate Wnt expression, of which, Wnt8 is crucial for neural crest development and other cell fates. In a study of morpholino based gene knockdown in zebrafish, knocking down Wnt8a resulted in the lack of expression of various other genes important for neural crest induction (pax3, sox10, and foxd3). It is unclear however, if the loss of these neural crest specifiers is a result of Wnt8a directly in the induction process or is a downstream consequence of disruptions in Wnt8a signaling earlier in development. Regardless, the results of this study show Wnt8a as a key player in neural crest induction.
Protein Wnt-8a (Protein Wnt-8d) WNT8A WNT8D
Human,Mouse,Rat
WB,IF,ICC,FC
WB 1:1000IF 1:100-1:400ICC 1:50FC 1:500-1:1000
Predicted band size: 38.8 kDa
WNT8A WNT8D
q9h1j5
Rabbit
Monoclonal
Rabbit IgG
HeLa cell lysate, HepG2 cell lysate, SW480 cell lysate, Jurkat cell lysate, Raji cell lysate, NIH/3T3 cell lysate, mouse brain tissue lysate, mouse embryo tissue lysate, rat brain tissue lysate, NIH/3T3, HeLa.
Protein A affinity purified.
PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Store at +4℃ after thawing. For long-term storage, please store it at -20℃. Avoid repeated freeze / thaw cycles.
艾比玛特医药科技（上海）有限公司
上海市徐汇区桂平路333号聚科生物园区1号楼1-3层
邮箱：market@ab-mart.com
应聘职位：hr@ab-mart.com
订购专线：4006-123-828
销售电话：13916964679（微信同号）
技术支持：15618194176（微信同号）
华南经销商负责（广东，广西，福建，海南）：
程经理：手机18616261485（微信同号）
华北经销商负责（北京，天津，河北）：
徐经理：手机15618191473（微信同号）
南方经销商负责：
陆经理：手机13122837132（微信同号）
北方及西南经销商负责：
张经理：手机13122150513（微信同号）
微信客服
邮箱：market@ab-mart.com
应聘职位：hr@ab-mart.com
订购专线：4006-123-828
销售电话：13916964679（微信同号）
技术支持：15618194176（微信同号）
华南经销商负责（广东，广西，福建，海南）：
程经理：手机18616261485（微信同号）
华北经销商负责（北京，天津，河北）：
徐经理：手机15618191473（微信同号）
南方经销商负责：
陆经理：手机13122837132（微信同号）
北方及西南经销商负责：
张经理：手机13122150513（微信同号）
微信客服
沪ICP备17056956号-2 艾比玛特医药科技（上海）有限公司
